Highly sensitive luminescent lanthanide metal-organic framework sensor for L-kynurenine  

作　　者：Ting Tang Min Liu Zhao Chen Xingxiang Wang Chunguang Lai Liwen Ding Chenghui Zeng 

机构地区：[1]Research Center for Ultra Fine Powder Materials,College of Chemistry and Chemical Engineering,Jiangxi Normal University,Nanchang 330022,China

出　　处：《Journal of Rare Earths》2022年第3期415-420,I0002,共7页稀土学报（英文版）

基　　金：Project supported by the National Natural Science Foundation of China(51962008);Jiangxi Provincial Natural Science Foundation(20202BABL203018)。

摘　　要：L-kynurenine(L-kyn)is a marker of prostate cancer.At present,the expensive instruments are usually applied to detect L-kyn clinically,which limits its wide application for cancer diagnosis.Herein,three lanthanide metal-organic frameworks([Ln(CHO_(2))_(3)]_(n),Ln=Eu,Gd,and Tb)were designed and obtained,and detailly characterized by single crystal X-ray diffraction(SCXRD),powder X-ray diffraction(PXRD),Fourier transform infrared spectroscopy(FT-IR),thermogravimetric analysis(TGA),and luminescence spectroscopy.Further study reveals that[Tb(CHO_(2))_(3)]_(n)is a highly selective,ultra-sensitive,of strong anti-interference,highly stable,and non-expensive sensor for prostate cancer marker L-kyn.The limit of detection(LOD)for L-kyn sensing is a highly sensitive value of 1.0×10^(−9)mol/L.Furthermore,the sensing mechanism is discussed in detail.

关 键 词：Sensitive Lanthanide metal-organic frameworks(LnMOFs) Sensor Prostate cancer marker L-kynurenine(L-kyn) Rare earths 

分 类 号：TG146.45[一般工业技术—材料科学与工程] TP212[金属学及工艺—金属材料]