病理性瘢痕易感体质及生物学防治的研究及启示  

Research and enlightenment of biological prevention and treatment regarding scar diathesis

作　　者：徐潇 陈康 陈敏亮[1] Xu Xiao;Chen Kang;Chen Minliang(Department of Plastic and Reconstructive Surgery in the Senior of Burns and Plastic Surgery,the Fourth Medical Center of Chinese PLA General Hospital,Beijing 100048,China;Medical School of Chinese PLA,Beijing 100853,China)

机构地区：[1]解放军总医院第四医学中心烧伤整形医学部整形修复科,北京100048 [2]解放军医学院,北京100853

出　　处：《中华整形外科杂志》2022年第2期126-131,共6页Chinese Journal of Plastic Surgery

基　　金：国家自然科学基金(81272103,81772085)。

摘　　要：病理性瘢痕包括局限性生长的增生性瘢痕和生长超过创缘的瘢痕疙瘩。瘢痕疙瘩具有难治性、易复发性的特点,单一的手术和非手术等传统治疗方法均无法取得良好的治疗效果。其发病机制至今尚未明确,涉及基因、细胞因子、炎症介质、免疫应答、环境等多方面因素,目前,学术界普遍认为瘢痕疙瘩有一定遗传倾向,由多基因、多因子共同作用所致。该文总结了作者团队2009年以来利用慢病毒基因转染、全基因重测序技术等,筛选汉族瘢痕疙瘩家系基因,初探瘢痕疙瘩的病因和基因治疗靶点,探索富含脂肪来源干细胞(ADSCs)的乳糜脂肪治疗增生性瘢痕的作用和机制研究等一系列成果,结合瘢痕疙瘩易感基因相关研究及ADSCs等生物学治疗的主要经验,提出了病理性瘢痕易感体质及生物学防治的新思路。Pathological repair after tissue injury is caused by massive deposition of collagenous extracellular matrix components,which can lead to pathological scar due to hyperplasia of dermal tissue,including hypertrophic scar with localized growth and keloid with growth beyond the wound edge.Keloids is difficult to treat and easy to relapse,single operation,non-operation and other traditional treatment method could not achieve good therapeutic effect.The pathogenesis of keloid is still unclear,involving genes,cytokines,inflammatory mediators,immune responses,environmental factors and many other factors.At present,the academic community generally believes that keloid has a certain genetic tendency,which is caused by the joint effect from multiple genes and factors.In this paper,the author summarized that their team has used lentivirus gene transfection,whole gene resequencing technology,GO annotation and signal pathway analysis to screen keloid genes in Han Chinese families since 2009,and preliminarized the etiology and gene therapy targets of keloid,then established an animal model of hypertrophic scar in nude mice.They explored the effect and mechanism research for the treatment of hyperplastic scar with Adipose derived stem cells(ADSCs)in chyle fat,combined with keloid susceptible gene related research and the main experience of the biological treatment by ADSCs,on the basis of the traditional sense of scar occurred and the treatment,proposed the new way of thinking in scar susceptible and biological prevention in the following summary.

关 键 词：瘢痕 易感基因 脂肪来源干细胞 乳糜化脂肪 

分 类 号：R622[医药卫生—整形外科]