多肽类辐射防护药物应用的研究进展  

Application research progress in polypeptides radioprotective agents

作　　者：杨婷仪 李晓倩 张杰 张舒羽 Yang Tingyi;Li Xiaoqian;Zhang Jie;Zhang Shuyu(Radiation Medicine Laboratory,West China School of Basic Medical Sciences&Forensic Medicine,Sichuan University,Chengdu 610041,China;Department of Radiation Protection Medicine,School of Military Preventive Medicine,Air Force Medical University,Xi'an 710032,China;Department of Nuclear Medicine,Nuclear Industry 416 Hospital,Chengdu 610051,China)

机构地区：[1]四川大学华西基础医学与法医学院放射医学研究室,成都610041 [2]空军军医大学军事预防医学系辐射防护医学教研室,西安710032 [3]核工业四一六医院核医学科,成都610051

出　　处：《国际放射医学核医学杂志》2021年第12期783-788,共6页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金(31770909、31770911);陕西省杰出青年科学基金(2018JC-013)。

摘　　要：近年来,核能与核技术在工业、医药、科技、军事等领域的广泛应用使人们暴露于辐射的风险增加,而临床上仍缺乏安全、高效的辐射防护药物。功能多肽在体内担负着重要的调节功能,且多肽类药物具有靶向性、高特异活性、药品安全性高、易于改造修饰等优势。因此,多肽类辐射防护药物的相关研究较多。笔者将对多肽类辐射防护药物的特性和设计思路及其应用进行综述,旨在为多肽类辐射防护药物的研究奠定基础。The potential risk of radiation exposure is increasing because of the widespread use of nuclear technologies in the fields of medicine,science,technology,and military and various industries.Moreover,safe and effective radioprotective agents are lacking.Polypeptides play a vital regulatory role in various living processes.Polypeptide drugs are highly selective,efficacious,and safe,and modifications are easy to incorporate for the optimization of peptide functionality.Hence,many studies on radioprotective polypeptides have been conducted.Here,we provide an overview of peptides as radioprotective agents,particularly their molecular characteristics,design ideas,and the specific therapeutic effects of potential radioprotective peptides,aiming to lay the groundwork for the research of radioprotective polypeptides.

关 键 词：肽类 辐射损伤 辐射防护剂 

分 类 号：R979.6[医药卫生—药品]