铁死亡在心血管疾病中的研究进展  

Research progress of ferroptosis in cardiovascular diseases

作　　者：王晓棣[1] 陈鑫[1] WANG Xiaodi;CHEN Xin(Department of Thoracic and Cardiovascular Surgeryy Nanjing First Hospital,Nanjing Medical Universityt Nanjing,210006,P.R.China)

机构地区：[1]南京医科大学附属南京医院南京市第一医院心胸血管外科,南京210006

出　　处：《中国胸心血管外科临床杂志》2022年第4期497-501,共5页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金青年项目(81900417)。

摘　　要：心血管疾病死亡高居我国居民死亡原因首位,对心血管疾病发病机制的深入探索具有重要意义。铁死亡是近年来发现的一种铁依赖的、非凋亡形式的调节性细胞死亡,参与调节多种生物学事件。研究发现铁死亡在心血管疾病的发生发展中发挥重要作用。本文根据近期文献报道,对铁死亡的机制与调控进行概括,并对其在心脏缺血-再灌注/心肌梗死、心肌病、心肌肥厚、动脉粥样硬化及腹主动脉瘤等常见心血管疾病中的研究成果进行阐述。Cardiovascular disease is a leading cause of death in Chinese population.It is of great significance to further explore the pathogenesis of cardiovascular diseases.Ferroptosis is a recently discovered iron-dependent and nonapoptotic form of regulated cell death,which exerts a regulatory role in a variety of biological events.Some studies have shown that ferroptosis plays an important role in the development of cardiovascular diseases.According to newly scientific reports,we summarized the mechanism and regulation in ferroptosis,and reviewed the results of ferroptosis in common cardiovascular diseases such as cardiac ischemia-reperfusion/myocardial infarction,cardiomyopathy,cardiac hypertrophy,atherosclerosis and abdominal aortic aneurysm.

关 键 词：铁死亡 铁蓄积 脂质过氧化 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]