新疆地区疑似支气管哮喘学龄前儿童低亲和力IgE受体、白三烯C4合成酶基因多态性分析  

IgE Low-Affinity Receptor and Leukotriene C4 Synthase Gene Polymorphisms in Preschool Children with Suspected Bronchial Asthma in Xinjiang

作　　者：王婷婷[1] 冯杰[1] 赵婷[1] 马兰红[1] 孙力[1] 于鲁海[1] 李红健[1] Wang Tingting;Feng Jie;Zhao Ting;Ma Lanhong;Sun Li;Yu Luhai;Li Hongjian(People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院,乌鲁木齐830001

出　　处：《儿科药学杂志》2022年第4期1-4,共4页Journal of Pediatric Pharmacy

摘　　要：目的:探讨低亲和力IgE受体(FCER2)基因T2206C位点、白三烯C4合成酶(LTC4S)基因A-444C位点基因型和等位基因在新疆地区哈萨克族、汉族、维吾尔族疑似支气管哮喘学龄前儿童中分布特征的差异性,为新疆不同民族学龄前支气管哮喘儿童的早期诊断提供参考。方法:采用荧光染色原位杂交方法检测245例新疆疑似支气管哮喘学龄前儿童(哈萨克族48例、维吾尔族68例、汉族129例)的FCER2 T2206C及LTC4S A-444C基因多态性,分析基因型频率和等位基因频率在不同民族及不同地区相同民族间是否存在差异。结果:新疆地区汉族患儿与维吾尔族、哈萨克族患儿LTC4S A-444C基因型频率及等位基因频率比较差异有统计学意义(P<0.05)。新疆地区汉族儿童与维吾尔族、哈萨克族患儿FCER2 T2206C基因型频率及等位基因频率比较差异无统计学意义(P>0.05)。结论:新疆不同民族疑似支气管哮喘学龄前儿童LTC4S A-444C的基因型与等位基因的分布频率存在差异。本研究为进一步探讨儿童支气管哮喘分子诊断方法、疾病预测及防治奠定了基础。Objective: To probe into the distribution characteristics of IgE low-affinity receptor(FCER2) gene T2206 C locus and leukotriene C4 synthase(LTC4 S) gene A-444 C locus genotypes and alleles in preschool children with suspected bronchial asthma of Xinjiang Kazak, Han and Uygur nationality, so as to provide early diagnosis reference for preschool children with bronchial asthma of different nationalities in Xinjiang. Methods: FCER2 T2206 C and LTC4 S A-444 C gene polymorphisms were detected by fluorescence staining in situ hybridization in 245 preschool children with suspected bronchial asthma in Xinjiang(48 cases of Kazak, 68 cases of Uygur and 129 cases of Han nationality). Differences of genotype frequency and allele frequency among different nationalities and different regions were analyzed. Results: There were statistically significant differences in LTC4 S A-444 C genotype frequency and allele frequency among children of Han, Uygur and Kazak nationality(P<0.05). There was no significant difference in FCER2 T2206 C genotype and allele frequency among children of Han, Uygur and Kazak nationality(P>0.05). Conclusion: There were significant differences in the distribution frequency of LTC4 S A-444 C genotype and allele in preschool children with suspected bronchial asthma of different nationalities in Xinjiang. This study lays a foundation for further exploration of molecular diagnostic methods, disease prediction and prevention and treatment of children with bronchial asthma.

关 键 词：低亲和力IgE受体 白三烯C4合成酶 学龄前儿童 支气管哮喘 新疆 

分 类 号：R725.6[医药卫生—儿科]