卵巢储备功能减退与体质类型及心理因素相关性研究  

Study on the Correlation of the Diminished Ovarian Reserve with Constitutional Types and Psychological Factors

作　　者：郭淼[1] 翟凤霞[1] 陈萍[1] 代文华 李娜[3] 李敏[3] 王炎炎 GUO Miao;ZHAI Feng-Xia;CHEN Ping;DAI Wen-Hua;LI Na;LI Min;WANG Yan-Yan(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450099 Henan,China;Zhumadian Traditional Chinese Medicine Hospital,Zhengzhou 463000 Henan,China;Postgraduate in 2018,Henan University of Chinese Medicine,Zhengzhou 450046 Henan,China;Postgraduate in 2019,Henan University of Chinese Medicine,Zhengzhou 450046 Henan,China)

机构地区：[1]河南中医药大学第一附属医院,河南郑州450099 [2]河南省驻马店市中医院,河南驻马店463000 [3]河南中医药大学,河南郑州450046

出　　处：《广州中医药大学学报》2022年第3期491-498,共8页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：河南省科技攻关项目(编号:182102311151);河南省中医药科学研究专项课题项目(编号:2019JDZX2104);国家中医药管理局第六批全国老中医药专家王丽娜学术经验继承项目(编号:国中医药人教发[2017]29号);胡玉荃全国名老中医药专家传承工作室建设项目(编号:2100601-CZ0098)。

摘　　要：【目的】探究卵巢储备功能减退(DOR)患者的易患体质和心理特征,分析DOR与体质类型及心理因素的相关性。【方法】对50例DOR患者(观察组)和50例卵巢储备功能正常女性(对照组)进行问卷调查,对问卷中的中医体质分类、生活事件量表(LES)、症状自评量表(90项症状清单,SCL-90)、艾森克人格问卷简式量表(EPQ-RSC)的调查结果进行组间比较,同时采用Logistic回归分析方法进行多因素相关性分析。【结果】(1)中医体质分布方面:观察组居前3位的体质类型为阳虚质[26.0%(13/50)]、气虚质[20.0%(10/50)]和气郁质[20.0%(10/50)];对照组的体质类型以平和质所占比例最高,占36.0%(18/50);组间比较,差异有统计学意义(P<0.01)。(2)生活事件方面:观察组的正性生活事件刺激量小于对照组,负性生活事件刺激量大于对照组,差异均有统计学意义(P<0.01)。(3)SCL-90评分方面:观察组的抑郁因子和焦虑因子评分均明显高于对照组(P<0.05或P<0.01),而2组的其他各项因子评分比较,差异均无统计学意义(P>0.05)。(4)EPQ-RSC评分方面:观察组的抑郁质和黏液质艾森克人格类型占比高于对照组,而对照组的多血质艾森克人格类型的占比高于观察组,组间比较,差异有统计学意义(P<0.01)。(5)经Logistic回归分析,阳虚质、气虚质、血瘀质、负性生活事件、正性生活事件、黏液质、抑郁质、多血质与DOR的发生存在相关性(P<0.05或P<0.01),其中以阳虚质、负性生活事件、黏液质与DOR的发生相关性较大。【结论】DOR患者常见体质类型多为阳虚质、气郁质和气虚质,受负性生活事件影响较大,同时可能有焦虑、抑郁的心理障碍倾向,且人格特征多为抑郁质、黏液质;另外,阳虚质、负性生活事件、黏液质与DOR的发生相关性较大。Objective To explore the physical constitution and psychological characteristics of patients with diminished ovarian reserve(DOR),and to investigate the correlation of DOR with the physical constitution types and psychological factors.Methods Fifty cases of DOR patients(observation group)and 50 cases of women with normal ovarian reserve function(control group)were surveyed by using questionnaire.The findings of the traditional Chinese medicine(TCM)constitutional classification,life event scale(LES),symptom self-rating scale of 90-item symptom checklist(SCL-90),and reversed simplified Chinese edition of Eysenck personality questionnaire(EPQ-RSC)were compared between the two groups,and Logistic regression analysis was used for the multivariate correlation analysis.Results(1)TCM constitution distribution:the top 3 constitution types in the observation group were yang deficiency constitution[26.0%(13/50)],qi deficiency constitution[20.0%(10/50)]and qi stagnation constitution[20.0%(10/50)].In the control group,the proportion of balanced quality was the highest(36.0%,18/50).The intergroup comparison showed that the difference was statistically significant(P<0.01).(2)Life events:the stimulus quantity of positive life events in the observation group was smaller while the stimulus quantity of negative life events was larger than those in the control group,the difference being statistically significant(P<0.01).(3)SCL-90 scores:the scores of depression factor and anxiety factor in the observation group were significantly higher than those in the control group(P<0.05 or P<0.01),while there were no significant differences in other factors scores between the two groups(P>0.05).(4)In terms of EPQ-RSC scores,the proportion of depressive personality and mucinous personality in the observation group was higher than that in the control group,while the proportion of sanguine personality in the control group was higher than that in the observation group,and the intergroup comparison showed that the difference was statistically signif

关 键 词：卵巢储备功能减退 中医体质类型 阳虚质 气郁质 气虚质 心理因素 艾森克人格类型 相关性分析 

分 类 号：R271.9[医药卫生—中西医结合]