25羟维生素D与2型糖尿病患者临床特征及生化指标的相关性分析  

作　　者：孙莉[1] 周善磊 许慕蓉 姜天[1] 代芳[1] 

机构地区：[1]安徽医科大学第一附属医院,230022

出　　处：《浙江临床医学》2022年第3期376-378,共3页Zhejiang Clinical Medical Journal

摘　　要：目的比较不同25羟维生素D[25(OH)D]水平2型糖尿病患者的临床特征及生化指标,了解维生素D在糖尿病控制方面的作用。方法收集2019年5月至2021年6月104例2型糖尿病患者的临床资料,按照25(OH)D水平将患者分为维生素D(VD)缺乏组和VD非缺乏组。分析25(OH)D的水平对2型糖尿病患者临床特征及生化指标的影响。结果VD缺乏组和VD非缺乏组患者在年龄、性别比例、病程、吸烟年数方面差异无统计学意义(P>0.05)。VD缺乏组患者收缩压和舒张压均比VD非缺乏组高(P<0.05)。两组患者生化指标中糖化血红蛋白、空腹血糖、餐后2hC肽、白蛋白、TC、HDL、LDL差异无统计学意义(P>0.05)。VD缺乏组血清肌酐、空腹C肽、TG、VLDL高于VD非缺乏组(P<0.05)。VD缺乏组25(OH)D、Hb、eGFR明显低于VD非缺乏组(P<0.05)。Spearman相关分析发现25(OH)D与患者收缩压呈负相关(P<0.05);与eGFR及血红蛋白呈正相关(P<0.05)。结论维生素D缺乏可能是导致或促使2型糖尿病患者血压(尤其是收缩压)升高、肾功能变差、胰岛素抵抗加重以及血红蛋白下降的危险因素。objective To compare the cliical characteristis and biochemical indicators of patients with type 2 diabetes mellitus with different levels of 25-hydroxyvitamin D[25(OH)D],and to find out the role of vitamin D in diabetes control.Methods A total of 104 patients with type 2 diabetes who were hospitalized in the Department of Endocrinology and Metabolism in our hospital from May 2019 to June 2021 were collected and divided into two groups according to 25(OH)D levels:vitamin D(VD)deficient group and VD non-deficient group.The clinical data of the two groups were retrospectively analyzed,and the effect of 25(OH)D levels on the clinical characteristics and biochemical indicators of patients with type 2 diabetes was investigated.Results No significant difference was observed between the VD deficient group and the VD non-deficient group in terms of age,sex ratio,course of the disease,and smoking years(P>0.05).Systolic blood pressure and diastolic blood pressure in the VD deficient group were higher than those in the VD non-deficient group(P<0.05).No statistically significant differences can be observed in the biochemical indicators of the two groups in glycosylated hemoglobin,fasting blood glucose,2h postprandial C-peptide,albumin,TC,HDL and LDL(P>0.05).The serum creatinine,fasting C-peptide,TG,VLDL of the VD deficient group were higher than those of the VD non-deficient group(P<0.05).Moreover,25(OH)D,Hb and eGFR of the VD deficient group were significantly lower than those of the VD non-deficient group(P<0.05).Spearman correlation analysis showed that 25(OH)D was negatively correlated with the systolic blood pressure of patients(P<0.05),and positively correlated with eGFR and hemoglobin(P<0.05).Conclusion Vitamin D deficiency may be a risk factor for increased blood pressure(especially systolic pressure),impaired kidney function,aggravated insulin resistance,and decreased hemoglobin in patients with type 2 diabetes mellitus.

关 键 词：糖尿病 维生素D 25羟维生素D 

分 类 号：R58[医药卫生—内分泌]