WASP家族在肿瘤发生发展中作用的研究进展  

Recent Advances of the Wiskott-aldrich Syndrome Protein Family Members in Tumorigenesis and Progression

作　　者：谢馨 陈艳 何志旭 黄佩 陈青华 XIE Xin;CHEN Yan;HE Zhixu;HUANG Pei;CHEN Qinghua(Affiliated Hospital of Zunyi Medical University/Hematology-Oncology Departmen of Guizhou Children's Hospital,Zunyi 563000,China)

机构地区：[1]遵义医科大学附属医院/贵州省儿童医院血液肿瘤科,贵州省遵义市563000

出　　处：《中国全科医学》2022年第14期1779-1789,共11页Chinese General Practice

基　　金：国家自然科学基金资助项目(82060675);贵州省科技计划项目(黔科合基础20201Y313);遵义医科大学学术新苗及创新探索专项(黔科合平台人才2017-5733-004);遵义医科大学附属医院科研启动基金(院字2018-09)。

摘　　要：恶性肿瘤的发生、发展是一个不断演进的过程,其具有侵袭、浸润和转移的基本生物学特征。WASP家族作为一类新型的肌动蛋白调节蛋白,是参与维持肌动蛋白细胞骨架的基本形态的关键成分,在维持细胞基础结构、细胞运动、细胞信号传导等在内的各种细胞过程中发挥着重要作用,同时也可介导肿瘤细胞的增殖、侵袭和转移。本文综述了WASP家族在肿瘤发生、发展中的作用,以及在不同肿瘤中的表达情况及其相关信号通路,提示WASP家族在肿瘤的发生及进展中存在广阔的研究空间,对于WASP家族在各种肿瘤中的机制研究、预后预测、甚至治疗等方面均有着重要意义。The development of cancer is an evolving process,with proliferation,invasion and metastasis as basic biological features.As a new class of actin regulatory proteins,Wiskott-aldrich syndrome protein(WASP)family is a key component in maintaining the basic morphology of actin cytoskeleton that is involved in many essential processes including maintaining basic structure of cells,and cell motility and signaling.It also mediates the proliferation,invasion and metastasis of cancer cells.We reviewed latest advances in the role of WASP family in cancer formation and progression,its expression levels in different cancers and related signaling pathways,suggesting that relevant research is highly promising,and reflecting the importance of WASP family in mechanisms of carcinogenesis,cancer treatment and prognosis prediction.

关 键 词：WASP家族 Wiskott-Aldrich综合征蛋白质家族 肿瘤 侵袭 肿瘤转移 综述 

分 类 号：R977.6[医药卫生—药品] R739.9[医药卫生—药学]