Acute kidney injury in traumatic brain injury intensive care unit patients  

作　　者：Zheng-Yang Huang Yong Liu Hao-Fan Huang Shu-Hua Huang Jing-Xin Wang Jin-Fei Tian Wen-XianZeng Rong-Gui Lv Song Jiang Jun-Ling Gao Yi Gao Xia-Xia Yu 

机构地区：[1]School of Biomedical Engineering,Health Science Center,Shenzhen University,Shenzhen 518037,Guangdong Province,China [2]Intensive Care Unit,Shenzhen Hospital,Southern Medical University,Shenzhen 518101,Guangdong Province,China [3]Department of Medicine,LKS Medical Faculty,The University of Hong Kong,Hongkong 999077,China

出　　处：《World Journal of Clinical Cases》2022年第9期2751-2763,共13页世界临床病例杂志

摘　　要：BACKGROUND The exact definition of Acute kidney injury(AKI)for patients with traumatic brain injury(TBI)is unknown.AIM To compare the power of the“Risk,Injury,Failure,Loss of kidney function,and End-stage kidney disease”(RIFLE),Acute Kidney Injury Network(AKIN),Creatinine kinetics(CK),and Kidney Disease Improving Global Outcomes(KDIGO)to determine AKI incidence/stage and their association with the inhospital mortality rate of patients with TBI.METHODS This retrospective study collected the data of patients admitted to the intensive care unit for neurotrauma from 2001 to 2012,and 1648 patients were included.The subjects in this study were assessed for the presence and stage of AKI using RIFLE,AKIN,CK,and KDIGO.In addition,the propensity score matching method was used.RESULTS Among the 1648 patients,291(17.7%)had AKI,according to KDIGO.The highest incidence of AKI was found by KDIGO(17.7%),followed by AKIN(17.1%),RIFLE(12.7%),and CK(11.5%)(P=0.97).Concordance between KDIGO and RIFLE/AKIN/CK was 99.3%/99.1%/99.3%for stage 0,36.0%/91.5%/44.5%for stage 1,35.9%/90.6%/11.3%for stage 2,and 47.4%/89.5%/36.8%for stage 3.The in-hospital mortality rates increased with the AKI stage in all four definitions.The severity of AKI by all definitions and stages was not associated with inhospital mortality in the multivariable analyses(all P>0.05).CONCLUSION Differences are seen in AKI diagnosis and in-hospital mortality among the four AKI definitions or stages.This study revealed that KDIGO is the best method to define AKI in patients with TBI.

关 键 词：Kidney Disease Improving Global Outcomes Acute Kidney Injury Traumatic brain injury EVALUATION In-hospital mortality 

分 类 号：R651.15[医药卫生—外科学] R692[医药卫生—临床医学]