Sarcomatoid intrahepatic cholangiocarcinoma with good patient prognosis after treatment with Huaier granules following hepatectomy:A case report  

作　　者：Ji-Ye Feng Xian-Peng Li Zong-Yang Wu Li-Ping Ying Chang Xin Zhen-Zhen Dai Yao Shen Yi-Feng Wu 

机构地区：[1]Department of Hepatobiliary&Pancreas Surgery,The Affiliated People’s Hospital of Ningbo University,Ningbo 315040,Zhejiang Province,China [2]Department of Infectious Disease,The Affiliated People’s Hospital of Ningbo University,Ningbo 315040,Zhejiang Province,China [3]Department of Pathology,The Affiliated People’s Hospital of Ningbo University,Ningbo 315040,Zhejiang Province,China [4]Department of Radiology,The Affiliated People’s Hospital of Ningbo University,Ningbo 315040,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2022年第9期2829-2835,共7页世界临床病例杂志

摘　　要：BACKGROUND Sarcomatoid intrahepatic cholangiocarcinoma(SICC)is an extremely rare and highly invasive malignant tumor of the liver.The precise pathologic mechanism of SICC has not been clearly identified,and the prognosis is very poor.The effectiveness of the treatment strategy of radical hepatectomy combined with Huaier granules has not yet been reported.CASE SUMMARY The patient was a 69-year-old male who presented with intermittent right upper abdominal pain for one month and 4-pound weight loss before admission.Abdominal magnetic resonance imaging and magnetic resonance cholangiopancreatography showed multiple stones in the bile ducts accompanied by dilatation of the intrahepatic and extrahepatic bile ducts.The preoperative diagnoses were right intrahepatic bile duct stones and extrahepatic bile duct stones;thus,surgical resection was performed.Choledochoscopy showed that the bile duct wall of the right anterior lobe was thickened,and a mass was visible in the duct.Then,a biopsy was performed,and rapid frozen-section biopsy analysis indicated that the tumor was malignant.The final diagnosis was SICC(T1a N0M0).Huaier granules were taken by the patient as anticancer therapy after surgery.The patient attended follow-up for 72 mo with no tumor recurrence or metastasis.CONCLUSION Sarcomatous intrahepatic cholangiocarcinoma is an extremely rare,aggressive malignancy,and the diagnostic gold standard is pathological diagnosis.We reported the first case of successful treatment with Huaier granules as anticancer therapy after surgery,which indicated that Huaier granules are safe and effective.Further studies are needed to study the anticancer molecular mechanisms of Huaier granules in sarcomatous intrahepatic cholangiocarcinoma.

关 键 词：Sarcomatous intrahepatic cholangiocarcinoma HEPATECTOMY Huaier granules DIAGNOSE Therapy Case report 

分 类 号：R657.3[医药卫生—外科学] R735.8[医药卫生—临床医学]