膝骨性关节炎合并骨质疏松症调节机制的研究进展  

Research progress on the regulatory mechanism of osteoart hritis of the knee combined with osteoporosis

作　　者：陈欣[1,2] 刘建军 董万涛 张兵刚 李宁 席芳琴[2] 宁学乾 巩彦龙 CHEN Xin;LIU Jianjun;DONG Wantao;ZHANG Binggang;LI Ning;XI Fangqin;NING Xueqian;GONG Yanlong(Gansu University of Chinese Medicine(TCM), Lanzhou 730000, China;Affiliated Hospital of Gansu University of Chinese Medicine(TCM), Lanzhou 730000, China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃中医药大学附属医院,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2022年第4期607-612,624,共7页Chinese Journal of Osteoporosis

基　　金：甘肃省青年科技基金(20JR10RA345);兰州市城关区科技计划项目(2020-2-2-7);甘肃中医药大学附属医院院内创新基金(gzfy-2019-12)。

摘　　要：膝骨性关节炎和骨质疏松症都是与年龄增长相关的骨与关节退行性疾病,两者在发病机制、病理变化、调节机制、临床治疗等方面存在着诸多的共同点,在膝骨关节炎和骨质疏松症的进程中通过复杂的调节机制维持骨代谢平衡、减轻炎症、保护关节软骨、稳定膝关节,进而延缓膝关节的退变;虽然两者间复杂的调节机制已有研究,但是仍然不完善。本研究从炎症、生物力学、激素与骨代谢、遗传、蛋白等方面对膝骨性关节炎并骨质疏松症的调节机制进行了综述,以期为临床防治该病提供新的思路和理论依据。Knee osteoarthritis and osteoporosis are degenerative diseases of bone and joint associated with increasing age.Both of them have common features in pathogenesis,pathological changes,regulatory mechanism and clinical treatment.In the process of knee osteoarthritis and osteoporosis,complex regulatory mechanisms are used to maintain the balance of bone metabolism,reduce inflammation,protect articular cartilage,stabilize the knee joint,and then delay the degeneration of the knee joint.Although the complex regulatory mechanisms between the two have been studied,they are still imperfect.In this study,we reviewed the regulatory mechanisms of knee osteoarthritis with osteoporosis from the aspects of inflammation,biomechanics,hormone and bone metabolism,genetics,and protein in order to provide new ideas and theoretical basis for clinical prevention and treatment of the disease.

关 键 词：膝骨性关节炎并骨质疏松症 调节机制 研究进展 

分 类 号：R683[医药卫生—骨科学]