Free fatty acids, glucose, and insulin in type 2 diabetes mellitus  

作　　者：Rob NM Weijers 

机构地区：[1]Teaching Hospital,OLVG,Amsterdam 95500,Netherlands

出　　处：《World Journal of Diabetes》2022年第3期275-277,共3页世界糖尿病杂志（英文版）（电子版）

摘　　要：Xu et al used the HOMA2 model to estimate theβ-cell function and insulin resistance levels in an individual from simultaneously measured fasting plasma glucose and fasting plasma insulin levels.This method is based on the assumption that the glucose-insulin axis is central for the metabolic activities,which led to type 2 diabetes.However,significant downregulation of both the NKX2-1 gene and the TPD52L3 gene force an increase in the release of free fatty acids(FFAs)into the blood circulation,which leads to a marked reduction in membrane flexibility.These data favor a FFA-glucose-insulin axis.The authors are invited to extend their study with the introduction of the saturation index(number of carbon-carbon double bonds per 100 fatty-acyl chains),as observed in erythrocytes.

关 键 词：Free fatty acids Membrane flexibility NKX2-1 gene RNA sequencing Type 2 diabetes TPD52L-3 gene Unsaturation index 

分 类 号：R587.1[医药卫生—内分泌]