新型冠状病毒肺炎感染两性差别研究进展  

Research progress on gender differences under novel coronavirus pneumonia

作　　者：周玉霞 姚晓文 王蓉(综述)[1] 张久聪(审校) ZHOU Yu-xia;YAO Xiao-wen;WANG Rong;ZHANG Jiu-cong(The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou 730030,Gansu,China;Department of Gastroenterology,The 940 Hospital of Joint Logistic Support Force of PLA,Lanzhou 730050,Gansu,China)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730030 [2]解放军联勤保障部队第九四○医院消化内科,兰州730050

出　　处：《东南国防医药》2022年第2期187-190,共4页Military Medical Journal of Southeast China

基　　金：火神山医院科研基金(HSS-217);联勤保障部队第九四○医院院内基金(20yjky020)。

摘　　要：新型冠状病毒肺炎由于其极强的传染力目前仍在全球范围内广泛流行,对人们的生命健康造成了极大威胁。然而,通过查阅研究既往文献资料发现,在感染率、危重状况和死亡率上存在性别上的差异。比起女性,男性在新冠肺炎中更容易被感染且病情更严重死亡率更高。首先,性别会对肾素-血管紧张素系统(RAS系统)中的关键成分血管紧张素转换酶-2的表达产生影响,这可能使两性在新冠肺炎的表现中产生差异。其次,由于女性有着积极快速强烈的免疫反应,而男性在遇到病原体时免疫反应相对处于弱势,这可能也是新冠肺炎下产生性别差异的原因之一。文章主要从RAS系统失衡和细胞因子风暴这两个新冠肺炎致病因素来对造成性别差异的潜在作用机制研究进展进行综述。The outbreak of COVID-19 in December 2019 poses a great threat to people′s lives and health because of its strong infectivity,which is still widespread worldwide.However,interestingly,by consulting previous literature,we found that there are gender differences ininfection rate,critical condition and mortality.Compared with women,men are more likely to be infected in novel coronavirus pneumonia and have higher mortality.First of all,gender will affect the expression of angiotensin converting enzyme-2(ACE2),a key component in the renin-angiotensin system(RAS system),which may lead to gender differences in the performance of novel coronavirus pneumonia.Secondly,because women have a positive,rapid and potent immune response,and men have a relatively weak immune response when encountering pathogens,this may also be one of the reasons for gender differences under novel coronavirus pneumonia.In this review,we briefly analyze the research progress in the hypothetical mechanism of gender differences from the two pathogenic factors of novel coronavirus pneumonia,RAS system imbalance and cytokine storm.

关 键 词：新型冠状病毒肺炎 性别差异 肾素-血管紧张素系统 血管紧张素转换酶-2 细胞因子风暴 

分 类 号：R18[医药卫生—流行病学]