温肾活血泄浊方对慢性肾脏病CKD3-4期脾肾阳虚湿瘀证患者血尿NGAL影响及疗效观察  

Effect of Wenshen Huoxue Xiezhuo Recipe on blood and urine NGAL in ckd3-4 patients with spleen kidney yang deficiency and dampness stasis syndrome

作　　者：赵珍 ZHAO Zhen(Department of Nephrology,Jiangning District Hospital of Traditional Chinese Medicine,Nanjing,Jiangsu,Nanjing 211100)

机构地区：[1]南京市江宁中医院,江苏南京211100

出　　处：《内蒙古中医药》2022年第2期87-89,共3页Inner Mongolia Journal of Traditional Chinese Medicine

摘　　要：目的:探讨对慢性肾脏病(CKD)CKD3-4期脾肾阳虚湿瘀证患者给予温肾活血泄浊方治疗的临床疗效,及对血尿NGAL等指标水平的影响。方法:纳入2020年1—12月南京市江宁中医院收治的符合标准的慢性肾脏病CKD3-4期脾肾阳虚湿瘀证患者60例为试验观察对象,按照随机数表法分为对照组和观察组,各30例。进行平行对照前瞻性研究。对照组给予常规方案治疗,观察组给予常规方案+温肾活血泄浊方加减治疗。比较两组治疗前后的中医症候积分、临床总有效率及治疗前后的肾功能指标(血肌酐Scr、尿氮素BUN、肾小球滤过率GFR、血尿酸UA)及血、尿中性粒细胞明胶酶相关载脂蛋白(NGAL)水平。结果:对照组与观察组治疗后血NGAL水平、尿NGAL水平均下降(P<0.05);观察组下降幅度更高,与对照组比较差异有统计学意义(P<0.05)。治疗后两组BUN、Scr与UA水平均呈下降趋势,且观察组下降更显著,与对照组治疗后比较差异有统计学意义(P<0.05);而UA差异无统计学意义(P>0.05);治疗后观察组GFR显著升高,且高于对照组(P<0.05)。治疗后组间中医证候积分总分比较显示观察组显著更低(P<0.05);观察组临床总有效率(90.00%,27/30)高于对照组(63.33%,19/30)(P<0.05)。结论:CKD3-4期脾肾阳虚湿瘀证患者给予温肾活血泄浊方治疗,疗效显著,可显著改善患者临床症状、肾功能,改善血尿NGAL水平,具有显著的临床推广应用价值。Objective:To investigate the clinical effect of Wenshen Huoxue Xiezhuo Decoction on chronic kidney disease(CKD)patients with ckd3-4 spleen kidney yang deficiency and dampness stasis syndrome,and its influence on blood and urine NGAL and other indicators.Methods:60 cases of ckd3-4 chronic kidney disease patients with spleen kidney yang deficiency and dampness stasis syndrome admitted to Jiangning Traditional Chinese medicine hospital from January 2020 to December 2020 were selected as the experimental observation objects.According to the random number table method,the patients were divided into the control group(30 cases)and the observation group(30 cases).The control group was given conventional treatment,and the observation group was given conventional treatment plus Wenshen Huoxue Xiezhuo decoction.The TCM symptom score,clinical total effective rate,renal function indexes(serum creatinine SCR,urinary nitrogen bun,glomerular filtration rate GFR,serum uric acid UA)and levels of neutrophil gelatinase associated apolipoprotein(NGAL)before and after treatment were compared between the two groups.Results:The blood NGAL level and urine NGAL level of the control group and the observation group were decreased after treatment,P<0.05;the decrease range of the observation group was higher,and the difference was significant compared with the control group,P<0.05.After treatment,bun,SCR and UA levels of the two groups showed a downward trend,and the observation group decreased more significantly,compared with the control group after treatment,the difference was statistically significant,P<0.05;while UA difference was not significant,P>0.05;after treatment,GFR of the observation group increased significantly,and higher than that of the control group,P<0.05.After treatment,the total score of TCM syndrome score in the observation group was significantly lower than that in the control group,P<0.05;the clinical total effective rate in the observation group was 90.00%(27/30),higher than 63.33%(19/30)in the control group,P<0.05.Con

关 键 词：慢性肾脏病 脾肾阳虚湿瘀证 温肾活血泄浊方 中医症候积分 

分 类 号：R692.9[医药卫生—泌尿科学]