过氧化物酶体增殖物活化受体γ的抗氧化作用  

Antioxidant Activity of PPARγ

作　　者：于慧杰 李峰生 魏仕楠 李伟 彭仁军 东肃河 王思念 陈忠民 江其生 YU Huijie;LI Fengsheng;WEI Shinan;LI Wei;PENG Renjun;DONG Suhe;WANG Sinian;CHEN Zhongmin;JIANG Qisheng(Department of Research,PLA Rocket Force Characteristic Medical Center,Beijing,100088,China;Training Base,PLA Rocket Force Characteristic Medical Center,Beijing,100088,China)

机构地区：[1]火箭军特色医学中心研究部,北京市100088 [2]火箭军特色医学中心培训基地,北京市100088

出　　处：《医学分子生物学杂志》2022年第2期177-180,共4页Journal of Medical Molecular Biology

摘　　要：过氧化物酶体增殖物活化受体(peroxisome proliferator activatived receptors,PPARs)是核受体超家族成员,包括PPARα、PPARδ和PPARγ3种亚型,他们在不同组织中表达,其中PPARγ在脂肪组织、心脏、肠道和免疫细胞中存在,在脂肪合成过程中起着关键作用。PPARγ具有抗氧化作用,通过调控Nrf2信号通路、内皮型NOS(eNOS)和诱导型NOS(iNOS)表达以及其他相关信号通路发挥作用。辐射诱导的氧化应激是引起细胞水平和全身水平损伤的主要因素,由于PPARγ具有抗氧化应激的能力,有望成为辐射防护和辐射治疗的有效靶点。Peroxisome proliferator activated receptors(PPARs),which includes PPARα,PPARδand PPARγ,belong to the superfamily of nuclear hormone receptors.The expression of the three isoforms of PPARs in different tissues showed distinct specificities.PPARγis present in the adipose tissue,heart,intestine,and immunocytes.It exerts important function in adipogenesis.PPARγis found to have the antioxidant activity,which may be through the Nrf2 signaling pathway,endothelial NOS(eNOS)expression,inducible NOS(iNOS)expression and some other related signaling pathways.Radiation-induced oxidative stress is the predominant factor that leads to the damage at both the cellular level and systemic level.As PPARγacts to protect from oxidative stress,it may serve as an effective radioprotective and radiotherapeutic target.

关 键 词：过氧化物酶体增殖物活化受体 γ 抗氧化作用 辐射防护 

分 类 号：R34[医药卫生—基础医学] R818.74