外泌体在脑靶向递送中的应用  

Application of exosomes in brain-targeted delivery

作　　者：李祺 王秀 杜丽娜[1,2] LI Qi;WANG Xiu;DU Li-na(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Beijing Institute of Radiation Medicine,Beijing 100850,China;College of Pharmacy,Bengbu Medical College,Bengbu 233030,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]军事科学院军事医学研究院辐射医学研究所,北京100850 [3]蚌埠医学院药学院,安徽蚌埠233030

出　　处：《药学学报》2022年第3期658-669,共12页Acta Pharmaceutica Sinica

基　　金：北京市自然科学基金面上项目(7202147);蚌埠市蚌埠医学院联合科技攻关项目(BYLK201823)。

摘　　要：血脑屏障(blood brain barrier, BBB)限制了大部分药物的脑靶向递送,进而影响神经系统疾病有效治疗。外泌体作为细胞衍生的纳米囊泡,可参与物质的细胞间运输、介导细胞间通讯和调节机体生物功能等,具有低免疫原性、低毒性及可天然跨越BBB的优点,在脑靶向递送中发挥重要作用。本文概括了外泌体分类、来源、脑靶向递送机制及其在脑部疾病中发挥的作用,为其临床应用提供参考。Brain-targeted delivery plays an important role in the diagnosis and treatment of neurological diseases, but the existence of blood brain barrier(BBB) limits the development of brain-targeted delivery. As cell-derived nanovesicles, exosomes can participate in the transportation of substances between cells to mediate the communication between cells to play a biological regulatory role in vivo. Due to the low immunogenicity, low toxicity, high engineering and natural crossing over BBB, exosomes play an important role in brain-targeted delivery. In this paper, the composition of exosomes, the mechanism of brain targeted delivery and its role in various brain diseases are systematically described.

关 键 词：外泌体 血脑屏障 脑靶向 药物递送 纳米囊泡 神经系统疾病 

分 类 号：R943[医药卫生—药剂学]