Mu阿片受体抑制肿瘤细胞增殖和促血管生成作用研究进展  

Research advances in the effect of Mu opioid receptors on tumor metastasis

作　　者：何志健 解康杰 袁俊波 方军 He Zhijian;Xie Kangjie;Yuan Junbo;Fang Jun(Wannan Medical College Graduate School,Wuhu 241002,China;Department of Anesthesiology,Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital),Hangzhou 310022,China)

机构地区：[1]皖南医学院研究生院,芜湖241002 [2]中国科学院大学附属肿瘤医院(浙江省肿瘤医院)麻醉科,杭州310022

出　　处：《国际麻醉学与复苏杂志》2022年第2期210-215,共6页International Journal of Anesthesiology and Resuscitation

基　　金：浙江省医药卫生科技项目面上项目(2018KY288)。

摘　　要：Mu阿片受体(Mu opioid receptor,MOR)是阿片类药物的主要作用受体,在肿瘤细胞中高度表达。有研究认为MOR对肿瘤的复发和转移有影响。MOR影响肿瘤复发和转移的作用机制繁杂,不同研究之间也存在争议。文章综述MOR及其亚型对肿瘤细胞的作用,不同的药物浓度差异对肿瘤细胞带来的不同影响,以及MOR通过多种信号通路、肿瘤微血管结构、内皮细胞对肿瘤血管生成的影响,以期为临床治疗中抑制肿瘤复发和转移提供理论参考。The Mu opioid receptor(MOR)is the main opioid receptor and is highly expressed in tumor cells.Some studies have suggested that MOR has an effect on tumor recurrence and metastasis.The mechanisms of MOR affecting tumor recurrence and metastasis are complicated and controversial among different studies.This paper reviews the role of MOR and MOR subtypes on tumor cells.And the role of MOR on tumor angiogenesis through multiple signaling pathways,tumor microvascular structure and endothelial cells.This review will provide a theoretical reference for the inhibition of tumor recurrence and metastasis in clinical treatment.

关 键 词：肿瘤细胞 Mu阿片受体 肿瘤转移 血管生成 

分 类 号：R965[医药卫生—药理学]