Immunoglobulin G4-related disease involving multiple systems:A case report  

作　　者：Yu-Qiong An Ning Ma Yong Liu 

机构地区：[1]Heart Center,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing 100045,China [2]Department of Ultrasound,Beijing-Shijitan Hospital,Capital Medical University,Beijing 100038,China

出　　处：《World Journal of Clinical Cases》2022年第8期2543-2549,共7页世界临床病例杂志

基　　金：Supported by Beijing Hospitals Authority Clinical Medicine Development of special funding support;No. XMLX202113;Beijing Municipal Science&Technology Commission;No. Z191100006619051;Special Fund for Open Topics of Lymph Surgery in Beijing Shijitan Hospital Affiliated to Capital Medical University;No. 2019-LB03;Beijing Natural Science Foundation;No. 7192062

摘　　要：BACKGROUND Ig G4-related disease(Ig G4-RD),an immune-mediated chronic progressive fibroinflammatory disease,can affect the functions of several organs.Some common characteristics can be observed in different Ig G4-RDs,such as higher prevalence in middle-aged and elderly male patients,raised serum Ig G4 levels,abundant infiltration of Ig G4-positive cells and fibrosis,diffuse or localized swelling of the affected organs,and good response to glucocorticoids treatment.CASE SUMMARY A 72-year-old man complained of left upper abdominal pain 3 mo ago,and he was diagnosed with acute onset of chronic cholecystitis and acute pancreatitis in the local hospital.Pain improved after relevant treatment.Several days ago,his abdominal pain worsened,and he was admitted to our hospital for further treatment.Doppler ultrasound showed that the pancreas presented with sausagelike swelling and the parenchymal echo was diffusely reduced.Gallbladder volume was increased,while the wall was rough and thickened with bilateral signs.Furthermore,the left submandibular gland was enlarged,accompanied with significantly increased blood flow signals.Finally,we found that the adventitia of the abdominal aorta and right iliac artery was thickened locally.Serum Ig G4 was elevated to 12600 mg/L.Therefore,the patient was diagnosed with Ig G4-RD.After treatment with methylprednisolone,he had an uneventful course and was discharged in good condition.CONCLUSION Ig G4-RD can involve almost any organs.Ultrasound has a significant role in timely and accurately diagnosis.

关 键 词：Immunoglobulin G4 Autoimmune pancreatitis CHOLECYSTITIS ARTERITIS ULTRASOUND Case report 

分 类 号：R593.2[医药卫生—内科学]