射干的研究进展及其质量标志物的预测分析  

Research grogress of Belamcanda Chinensis and predictive analysis of its quality markers

作　　者：凌悦 陈金鹏 叶晴 刘怡妙 徐旭[2,3,4] 田成旺 LING Yue;CHEN Jin-peng;YE Qing;LIU Yi-miao;XU Xu;TIAN Cheng-wang(Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Tianjin Institute of Pharmaceutical Research,Tianjin 300301,China;Tianjin Key Laboratory of Quality Marker of Traditional Medicine,Tianjin 300301,China;State Key Laboratory of Drug Delivery and Pharmacokinetics,Tianjin Institute of Pharmaceutical Research,Tianjin 300301,China)

机构地区：[1]天津中医药大学,天津300193 [2]天津药物研究院,天津300301 [3]天津市中药质量标志物重点实验室,天津300301 [4]释药技术与药代动力学国家重点实验室,天津300301

出　　处：《中草药》2022年第5期1595-1608,共14页Chinese Traditional and Herbal Drugs

基　　金：国家重大新药创制专项(2019ZX09201005);国家自然科学基金青年科学基金项目(82003936);中医药国际合作专项(基地类项目)(0610-2140NF020630)。

摘　　要：射干Belamcanda Chinensis是我国常用的中药材,资源丰富,分布较广,具有广阔的开发利用前景。射干中化学成分类型较为丰富,主要为黄酮类、三萜类、挥发油、甾体类等,一般认为异黄酮为其主要药效成分。在射干化学成分、药理作用综述的基础上,根据中药质量标志物(quality marker,Q-Marker)理论,从化学成分与传统功效、传统药性、可测成分、不同产地和采收时期、入血成分及不同配伍环境几方面对射干Q-Marker成分进行预测分析,发现以鸢尾苷、鸢尾黄素、野鸢尾黄素、白射干素、芒果苷表现最为显著,为明确射干Q-Marker和制定科学的质量标准提供理论基础。Belamcanda Chinensis is a commonly used Chinese medicinal material in China,which has abundant resources,wide distribution and broad prospects for development and utilization.The chemical compositions are rich in B.chinensis,including flavonoids,triterpenes,volatile oils,steroids.etc.Traditionally,isoflavones are considered to be the main medicinal ingredients.Based on the summarization of its chemical components and pharmacological effects,the Q-Markers of B.chinensis are predicted from the aspects of chemical components,traditional properties,detectable components,different producing areas,collecting periods,components entering blood and different compatibility environments.It was found that iris,iris flavin,wild kite flavin,eucalyptin and mangiferin were the most significant,which can provide basis for clarifying the Q-Markers and establishing scientific quality standards of B.chinensis.

关 键 词：射干 异黄酮 质量标志物 鸢尾苷 鸢尾黄素 野鸢尾黄素 白射干素 芒果苷 

分 类 号：R28[医药卫生—中药学]