五味子属植物木脂素类化学成分及其药理作用研究进展  

Research progress on lignans and pharmacological activities in plants of Schisandra

作　　者：刘媛媛 黄仕其 李玉泽[1] 樊浩 张化为[1] 邓翀 宋小妹[1] 张东东[1] 王薇[1] LIU Yuan-yuan;HUANG Shi-qi;LI Yu-ze;FAN Hao;ZHANG Hua-wei;DENG Chong;SONG Xiao-mei;ZHANG Dong-dong;WANG Wei(College of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学药学院,陕西咸阳712046

出　　处：《中草药》2022年第6期1903-1918,共16页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82174111);陕西省科技厅自然科学基础研究计划项目(2021JQ-744);陕西省重点研发计划项目(2019ZDLSF04-03-02);陕西中医药大学学科创新团队项目(2019-YL12)。

摘　　要：五味子属Schisandra隶属于五味子科,主要含有木脂素类、三萜类、多糖类以及挥发油等化学成分,临床上常用于治疗肝炎、肝肾移植、阿尔茨海默症和失眠等疾病。现代研究表明五味子属中木脂素类成分为该属植物的主要活性成分,具有保肝、抗肿瘤、抗病毒、抗氧化和神经保护等药理作用。对五味子属植物中木脂素类化学成分及其药理作用的研究进展进行综述,为后续该属植物的相关研究开发和综合应用提供参考。Schisandra belongs to the Schisandracea family.It mainly contains chemical components such as lignans,triterpenes,polysaccharides and volatile oils and is widely used in treatment of hepatitis,liver and kidney transplantation,Alzheimer’s disease,insomnia and other diseases.Modern studies have shown that lignans are the main active components of Schisandra,with pharmacological effects such as liver protection,antitumor,antivirus,anti-oxidant and neuroprotection.Research progress on lignans and pharmacological activities in plants of Schisandra are summarized in this paper,in order to provide references for the research and development and comprehensive application of Schisandra.

关 键 词：五味子属 木脂素类 联苯环辛烯型木脂素 保肝 抗肿瘤 抗氧化 

分 类 号：R282.710.5[医药卫生—中药学]