Washed microbiota transplantation reduces serum uric acid levels in patients with hyperuricaemia  

作　　者：Jin-Rong Cai Xin-Wen Chen Yu-Jian He Bin Wu Min Zhang Li-Hao Wu 

机构地区：[1]School of Clinical Medicine,Guangdong Pharmaceutical University,Guangzhou 510030,Guangdong Province,China [2]Department of Epidemiology and Health Statistics,Guangdong Pharmaceutical University,Guangzhou 510220,Guangdong Province,China [3]Department of Gastroenterology,The First Affiliated Hospital of Guangdong Pharmaceutical University,Guangzhou 510030,Guangdong Province,China [4]Research Center,Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province,Guangzhou 510030,Guangdong Province,China

出　　处：《World Journal of Clinical Cases》2022年第11期3401-3413,共13页世界临床病例杂志

基　　金：Supported by the Innovation and Entrepreneurship Training Program for College Students of Guangdong Province,No. S201910573028

摘　　要：BACKGROUND Previous studies have found that hyperuricaemia(HUA)is closely related to intestinal flora imbalance.AIM The current study investigated the effects and safety of washed microbiota transplantation(WMT)on serum uric acid(SUA)levels in different populations.METHODS A total of 144 patients who received WMT from July 2016 to April 2020 in the First Affiliated Hospital of Guangdong Pharmaceutical University and had SUA data before treatment were selected.Changes in SUA levels before and after treatment were retrospectively reviewed based on short-term and mid-term effects of WMT regimens.SUA levels measured in the last test within 3 mo after the first WMT represented the short-term effect,and SUA levels measured in the last test within 3-6 mo after the first WMT represented the mid-term effect.The patients were divided into an HUA group(SUA>416μM)and a normal uric acid(NUA)group(SUA≥202μM to≤416μM)based on pretreatment SUA levels.RESULTS Average short-term SUA levels in the HUA group decreased after WMT(481.00±99.85 vs 546.81±109.64μM,n=32,P<0.05)in 25/32 patients and returned to normal in 10/32 patients.The shortterm level of SUA reduction after treatment moderately correlated with SUA levels before treatment(r=0.549,R²=0.300,P<0.05).Average SUA levels decreased after the first and second courses of WMT(469.74±97.68 vs 540.00±107.16μM,n=35,and 465.57±88.88 vs 513.19±78.14μM,n=21,P<0.05).Short-term and mid-term SUA levels after WMT and SUA levels after the first,second and third courses of WMT were similar to the levels before WMT in the NUA group(P>0.05).Only 1/144 patients developed mild diarrhea after WMT.CONCLUSION WMT reduces short-term SUA levels in patients with HUA with mild side effects but has no obvious effect on SUA levels in patients with NUA.

关 键 词：Washed microbiota transplantation HYPERURICAEMIA Intestinal flora Effect SAFETY Retrospective study 

分 类 号：R589.7[医药卫生—内分泌]