Pulmonary Cladosporium infection coexisting with subcutaneous Corynespora cassiicola infection in a patient:A case report  

作　　者：Wei-Yi Wang Hong-Bin Luo Jun-Qi Hu Hui-Hua Hong 

机构地区：[1]Department of Respiratory Medicine,The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Traditional Chinese Medicine),Hangzhou 310006,Zhejiang Province,China [2]Department of Dermatology,The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Traditional Chinese Medicine),Hangzhou 310006,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2022年第11期3490-3495,共6页世界临床病例杂志

摘　　要：BACKGROUND Cladosporium and Corynespora cassiicola(C.cassiicola)infections rarely occur in humans.Mutations in human caspase recruitment domain protein 9(CARD9)are reported to be associated with fungal diseases.Pulmonary Cladosporium infection coexisting with subcutaneous C.cassiicola infection in a patient with a CARD9 mutation has not been reported in the literature.CASE SUMMARY A 68-year-old male patient was hospitalized for hypertrophic erythema and deep ulcers on the left upper extremity.He was diagnosed with pneumonia caused by Cladosporium,as identified through bronchoalveolar lavage fluid analysis,and deep dermatophytosis caused by C.cassiicola,as identified through morphological characteristics of the wound secretion culture.He underwent antifungal therapy(voriconazole)and recovered successfully.He carried two mutations in CARD9(chr9:139266425 and chr9:139262240)and was therefore susceptible to fungal infections.CONCLUSION This case study is the first to report the coexistence of pulmonary Cladosporium infection and subcutaneous C.cassiicola infection in a patient with CARD9 mutation.Our findings will be helpful in enriching the phenotypic spectrum of fungal infections underlying CARD9 deficiency.

关 键 词：CLADOSPORIUM Corynespora cassiicola Caspase recruitment domain protein 

分 类 号：R563.1[医药卫生—呼吸系统]