Qingchang decoction retention enema may induce clinical and mucosal remission in left-sided ulcerative colitis: A case report  

作　　者：Pei-Han Li Yu Tang Hong-Zhu Wen 

机构地区：[1]Department of Gastroenterology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China [2]Department of Basic Medicine,Fudan University,Shanghai 200032,China

出　　处：《World Journal of Clinical Cases》2022年第11期3573-3578,共6页世界临床病例杂志

基　　金：Supported by National Natural Science Foundation of China,No. 81703986

摘　　要：BACKGROUND Ulcerative colitis(UC)is a chronic autoimmune disease characterized by relapsing-remitting abdominal pain,diarrhea,mucopurulent discharge and rectal bleeding.To date,the etiology of the disease remains unknown;therefore,medical therapy is not yet available.Left-sided UC is mainly treated with oral and topical mesalazine.However,due to its modest clinical effect,endoscopic mucosal remission is not achieved in all patients.CASE SUMMARY A 44-year-old man presented to Longhua Hospital with a history of left-sided UC for more than 6 years and slight bloody diarrhea over time.Endoscopy suggested hyperemia,edema,and erosive mucosa involving the rectum and sigmoid colon.The Traditional Chinese medicine Qingchang decoction(QCD)enema treatment was initiated once a day combined with a previous standard dose of mesalazine for 8 wk,and rectal bleeding ceased after 4 wk of treatment.Another QCD enema treatment was provided after symptom relapse due to drug withdrawal for nearly 6 mo.At the 2-mo follow-up,the colonoscopy results indicated mucosal healing with no erosion or ulcers.CONCLUSION The Chinese formula QCD retention enema represents a potential treatment for left-sided UC with predominant rectal bleeding to achieve clinical and mucosal remission.

关 键 词：Ulcerative colitis Chinese formulas Qingchang decoction enema Qingchang suppository Case report 

分 类 号：R259[医药卫生—中西医结合]