Assessment of pathogens and risk factors associated with bloodstream infection in the year after pediatric liver transplantation  

作　　者：Yeong Eun Kim Ho Jung Choi Hye-Jin Lee Hyun Ju Oh Mi Kyoung Ahn Seak Hee Oh Jung-Man Namgoong Dae Yeon Kim Won Kyoung Jhang Seong Jong Park Dong-Hwan Jung Deok Bog Moon Gi-Won Song Gil-Chun Park Tae-Yong Ha Chul-Soo Ahn Ki-Hun Kim Shin Hwang Sung Gyu Lee Kyung Mo Kim 

机构地区：[1]Department of Pediatrics,Asan Medical Center Children's Hospital,University of Ulsan College of Medicine,Seoul 05505,South Korea [2]Division of Pediatric Surgery,Department of Surgery,Asan Medical Center Children's Hospital,University of Ulsan College of Medicine,Seoul 05505,South Korea [3]Division of Hepatobiliary Surgery and Liver Transplantation,Department of Surgery,Asan Medical Center,University of Ulsan College of Medicine,Seoul 05505,South Korea

出　　处：《World Journal of Gastroenterology》2022年第11期1159-1171,共13页世界胃肠病学杂志（英文版）

基　　金：Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI);Ministry of Health&Welfare,Republic of Korea,No.HR21C0198。

摘　　要：BACKGROUND Bloodstream infection(BSI)is one of the most significantly adverse events that can occur after liver transplantation(LT)in children.AIM To analyze the profile of BSI according to the postoperative periods and assess the risk factors after pediatric LT.METHODS Clinical data,collected from medical charts of children(n=378)who underwent primary LT,were retrospectively reviewed.The primary outcome considered was BSI in the first year after LT.Univariate and multivariate analyses were performed to identify risk factors for BSI and respective odds ratios(ORs).RESULTS Of the examined patients,106(28%)experienced 162 episodes of pathogen-confirmed BSI during the first year after LT.There were 1.53±0.95 episodes per children(mean±SD)among BSIcomplicated patients with a median onset of 0.4 mo post-LT.The most common pathogenic organisms identified were Coagulase-negative staphylococci,followed by Enterococcus spp.and Streptococcus spp.About half(53%)of the BSIs were of unknown origin.Multivariate analysis demonstrated that young age(≤1.3 year;OR=2.1,P=0.011),growth failure(OR=2.1,P=0.045),liver support system(OR=4.2,P=0.008),and hospital stay of>44 d(OR=2.3,P=0.002)were independently associated with BSI in the year after LT.CONCLUSION BSI was frequently observed in patients after pediatric LT,affecting survival outcomes.The profile of BSI may inform clinical treatment and management in high-risk children after LT.

关 键 词：Bloodstream infection Liver transplantation CHILDREN PATHOGENS 

分 类 号：R726.5[医药卫生—儿科]