CRISPR/Cas9基因编辑技术在心血管疾病研究中的应用进展  

Research advances on clustered regularly interspaced short palindromic repeats and CRISPR‑associated protein 9 gene edit‑ing in cardiovascular disease

作　　者：吴超[1] 何淑芳[1] Wu Chao;He Shufang(Department of Anesthesiology and Perioperative Medicine,the Second Hospital of Anhui Medical University,Key Laboratory of Anesthesi-ology and Perioperative Medicine of Anhui Higher Education Institutes,Anhui Medical University,Hefei 230601,China)

机构地区：[1]安徽医科大学第二附属医院麻醉与围术期医学科,麻醉与围术期医学安徽普通高校重点实验室(安徽医科大学),合肥230601

出　　处：《国际麻醉学与复苏杂志》2022年第3期322-326,共5页International Journal of Anesthesiology and Resuscitation

基　　金：安徽高校自然科学研究项目(KJ2020A0212);安徽医科大学第二附属医院国家自然科学基金孵育计划(2019GMFY01);安徽医科大学科研平台基地建设提升计划项目(2020xkjT060)。

摘　　要：成簇规律间隔的短回文重复序列及其相关蛋白9(clustered regularly interspaced short palindromic repeats and CRISPR‑associated protein 9,CRISPR/Cas9)基因编辑技术是一种能够通过DNA剪接而治疗多种疾病的基因编辑系统。该技术具有灵活简单、高效的优势,更重要的是能够同时编辑多个基因。近年来已经广泛应用于各个领域,在心血管领域中也取得了极大的进步。文章综述了CRISPR/Cas9基因编辑技术在心血管疾病研究中的应用进展,总结和列举基于CRISPR/Cas9基因编辑技术在心血管疾病预防和治疗中的应用,为心血管疾病治疗开创新方法提供参考。Clustered regularly interspaced short palindromic repeats and CRISPR‑associated protein 9(CRISPR/Cas9)gene editing technology is a gene‑editing system that can treat a variety of diseases by splicing DNA.The technique has the advantages of be‑ing flexible,simple,efficient and,more importantly,able to edit multiple genes simultaneously.CRISPR/Cas9 gene editing technology has been widely used in various fields in recent years,including great advances in the cardiovascular field.In this review,the applica‑tion advances of CRISPR/Cas9 gene editing technology in cardiovascular disease research is summarized and the application of CRIS‑PR/Cas9 gene editing technology in the prevention and treatment of cardiovascular disease is described and listed,so as to provide ref‑erence for creating new methods in the treatment of cardiovascular disease.

关 键 词：成簇规律间隔的短回文重复序列及其相关蛋白9 基因编辑 心血管疾病 基因治疗 

分 类 号：R54[医药卫生—心血管疾病]