宽胸气雾剂联合常规疗法治疗寒凝血瘀型冠心病稳定性心绞痛随机对照研究  

Randomized Controlled Trial of Kuanxiong Aerosol Combined Conventional Treatment on Stable Angina Pectoris of Coronary Heart Disease with Cold Coagulation and Blood Stasis Syndrome

作　　者：方金燕 冯月红[2] 王佳薇 陈方慧 章浩 徐远胜 沈国英 王弋[1] FANG Jin-yan;FENG Yue-hong;WANG Jia-wei;CHEN Fang-hui;ZHANG Hao;XU Yuan-sheng;SHEN Guo-ying;WANG Ge(Department of Emergency,Hangzhou First People's Hospital affiliated to Zhejiang University School of Medicine,Hangzhou,310006;Clinic of Zhejiang Economic and Trade Vocational and Technical College,Hangzhou,310018;Department of Endocrinology,903 Hospital of PLA Joint Logistic Support Force,Hangzhou,310013)

机构地区：[1]浙江大学医学院附属杭州市第一人民医院急诊科,杭州310006 [2]浙江经贸职业技术学院医务室,杭州310018 [3]联勤保障部队第九〇三医院内分泌科,杭州310013

出　　处：《中国中西医结合杂志》2022年第2期172-175,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：浙江省中医药科技计划项目(No.2019ZB099)。

摘　　要：目的观察宽胸气雾剂治疗寒凝血瘀型冠心病稳定性心绞痛的临床疗效。方法110例寒凝血瘀型冠心病心绞痛患者随机分为研究组和对照组各55例。其中对照组患者采用西医常规治疗,研究组在对照组基础上加用宽胸气雾剂治疗,治疗4周。比较两组治疗前后中医证候积分、心电图改善、每周心绞痛发作频次及持续时间、西雅图量表评分、血清一氧化氮(NO)、内皮素1(ET-1)、血管内皮生长因子(VEGF)水平。结果研究组中医证候疗效及心电图有效率(90.90%、69.09%)高于对照组(72.72%,49.09%,P=0.013,P=0.032)。与本组治疗前比较,两组治疗后心绞痛发作频次和持续时间及ET-1水平下降(P<0.05,P<0.01),西雅图量表评分及NO、VEGF水平增加(P<0.05,P<0.01)。与对照组同期比较,治疗组治疗后心绞痛发作频次和持续时间及ET-1水平下降(P<0.05,P<0.01),西雅图量表评分及NO、VEGF水平增加(P<0.05,P<0.01)。两组患者未见明显不良反应。结论宽胸气雾剂治疗冠心病稳定性心绞痛,可显著改善患者心电图缺血改变,减少心绞痛发作次数及持续时间,改善患者血管内皮功能。Objective To observe the clinical efficacy of Kuanxiong Aerosol(KA)in the treatment of stable angina pectoris of coronary heart disease with cold coagulation and blood stasis syndrome.Methods Totally 110 stable angina pectoris of coronary heart disease patients with cold coagulation and blood stasis syndrome were randomly assigned to study group and control group,55 cases in each group.The control group was treated with conventional Western medicine,and the study group was treated with KA and conventional Western medicine.Both groups were continuously treated for 4 weeks.The Chinese medicine syndrome score(CMSS),electrocardiogram,weekly frequency and duration of angina attacks,Seattle Scale Score(SSS),serum nitric oxide(NO)、endothelin 1(ET-1),vascular endothelial growth factor(VEGF)level were compared between the two groups before and after treatment.Results The effective rates of CMSS(90.90%vs 72.72%,P=0.013,)and electrocardiogram(69.09%vs 49.09%,P=0.032)were higher in the study group than in the control group.Compared with before treatment,the frequency and duration of angina attacks and serum ET-1 levels decreased(P<0.05,P<0.01),SSS,serum NO and VEGF levels increased(P<0.05,P<0.01)in both groups after treatment.Compared with control group,the frequency and duration of angina attacks and serum ET-1 levels decreased(P<0.05,P<0.01),SSS,serum NO and VEGF levels increased in the study group(P<0.05,P<0.01).No significant adverse effects were observed in both groups.Conclusions KA has significant clinical efficacy in treating patients with angina pectoris of coronary heart disease.It can significantly improve the efficacy of electrocardiogram,the frequency and duration of angina attacks,as well as the vascular endothelial function of patients.

关 键 词：冠心病稳定性心绞痛 芳香温通疗法 宽胸气雾剂 中西医结合疗法 中成药 随机对照研究 

分 类 号：R541.4[医药卫生—心血管疾病]