上海市社区居民戊型病毒性肝炎亚临床感染现状及其影响因素分析  

Subclinical infection of hepatitis E and its influencing factors among community residents in Shanghai

作　　者：肖正斌 陈恺韵 王琳[2] 屈凌霄 陈丹 任宏[3] XIAO Zheng-bin;CHEN Kai-yun;WANG Lin(Department of Epidemiology,School of Public Health,Fudan University,Shanghai 200032,China;不详)

机构地区：[1]复旦大学公共卫生学院流行病学教研室,上海200032 [2]上海市杨浦区疾病预防控制中心 [3]上海市疾病预防控制中心

出　　处：《中国公共卫生》2022年第3期266-270,共5页Chinese Journal of Public Health

基　　金：上海市卫生局局级课题(201840117)。

摘　　要：目的了解上海市社区居民戊型病毒性肝炎(戊肝)亚临床感染现状及其影响因素,为戊肝的综合防治提供科学依据。方法于2018年5-12月采用多阶段概率比例随机抽样方法在上海市16个区32个社区抽取4661名社区居民进行戊肝血清流行病学调查,并应用两水平多因素logistic回归模型分析社区居民戊肝亚临床感染的影响因素。结果上海市4661名社区居民中,戊肝肝炎病毒HEV-IgG或HEV-IgM抗体阳性者1217例,戊肝亚临床感染率为26.11%。两水平多因素非条件logistic回归分析结果显示,男性、年龄≥5岁、离退休人员、偶尔喝生水、半年内做过肝炎检测和半年内吃过生鲜刺身是上海市社区居民戊肝亚临床感染的危险因素,外地户籍、接种戊肝疫苗情况不详和饭前便后经常洗手是上海市社区居民戊肝亚临床感染的保护因素。结论上海市社区居民戊肝亚临床感染率较高,性别、年龄、职业、户籍、喝生水情况、半年内做肝炎检测情况、接种戊肝疫苗情况、半年内是否吃过生鲜刺身和饭前便后是否经常洗手是该地区社区居民戊肝亚临床感染的主要影响因素。Objective To investigate the prevalence and influencing factors of subclinical infection of hepatitis E virus(HEV)in Shanghai community residents for providing evidences to comprehensive prevention and treatment of hepatitis E.Methods With multistage probability proportional-to-size random sampling,we conducted a seroepidemiological survey among 4661 permanent residents(aged 1-69 years)in 32 urban communities/rural villages in 16 districts of Shanghai city during May-December 2018.The participants had face-to-face interviews with a self-designed questionnaire and detections of serum HEV immunoglobulin G(IgG)and immunoglobulin M(IgM)by enzyme-linked immunosorbent assay(ELISA).Binary multivariate logistic regression analysis was adopted to explore influencing factors of subclinical HEV infection.Results Of all the participants,26.11%(1217)were positive for HEV-IgG or HEV-IgM antibody.The results of regression analysis revealed that the risk factors of subclinical HEV infection included male gender,five years old and above,drinking unboiled water occasionally,being retired,having hepatitis related detection during past six months,and consuming fresh sashimi during past six months;the results also showed that with a non-local registered residence,being not sure about a history of having HEV vaccination,and washing hands before eating and after using bathroom were protective factors against HEV infection.Conclusion Among urban and rural community residents of Shanghai city,the prevalence of HEV subclinical infection was relatively high and influenced mainly by gender,age,occupation,registered residence,whether drinking unboiled water,history of HEV vaccination,and the status of having hepatitis-related test/consuming fresh sashimi during past six months.

关 键 词：戊型病毒性肝炎(戊肝) 亚临床感染 影响因素 社区居民 

分 类 号：R512.6[医药卫生—内科学] R181.3[医药卫生—临床医学]