深圳市罗湖区乙型病毒性肝炎综合干预效果评估  

Effect of comprehensive intervention on hepatitis B in Luohu district of Shenzhen city

作　　者：张世洁 陈伟红[3] 刘卫民[3] 陈国翠[3] 郭志伟 李拥彬 廖异 刘刚[2] 祝方 周小红 程锦泉[1,2] ZHANG Shi-jie;CHEN Wei-hong;LIU Wei-min(College of Public Health,Zhengzhou University,Zhengzhou,Henan Province 450000,China;不详)

机构地区：[1]郑州大学公共卫生学院,河南郑州450000 [2]深圳市疾病预防控制中心 [3]深圳市罗湖区疾病预防控制中心 [4]深圳市罗湖区中医院

出　　处：《中国公共卫生》2022年第3期276-279,共4页Chinese Journal of Public Health

基　　金：国家科技重大专项(2018zx10715004);中国乙肝防控科研基金(YGFK20190038)。

摘　　要：目的调查分析深圳市罗湖区2010-2020年乙肝携带、新发感染和乙肝相关疾病死亡率流行特征,评估示范区乙肝综合防治效果。方法利用多阶段整群随机抽样的方法,分别于2010年和2020年对罗湖区进行乙肝携带率调查,同时收集了示范区罗湖区和对照区龙岗区2010-2020年乙肝新发感染、乙肝相关疾病死亡及人口学资料,运用描述性流行病学的方法,分析罗湖区乙肝携带率、新发感染率和相关疾病死亡率的现况和变化趋势。结果罗湖区2010年和2020年标化后的乙肝携带率分别为8.74%和6.91%,差异具有统计学意义(P<0.01)。乙肝新发感染率由2010年的2.88/10万下降至2020年的0.09/10万,下降了96.88%。乙肝相关疾病的标准化死亡率2010年和2020年分别为5.36/10万和5.67/10万,变化趋势整体呈平稳状态,差异无统计学意义(P=0.561)。罗湖区与龙岗区横向比较显示,2010-2020年罗湖区乙肝新发感染率均低于龙岗区,差异均有统计学意义(P<0.05);罗湖区在2010-2015年内乙肝相关疾病的标准化死亡率均高于龙岗区,2016-2017年两区基本持平,自2018年起,罗湖区低于龙岗区,差异有统计学意义(P<0.05)。结论病毒性肝炎综合防治重大科技专项在深圳市罗湖区经过10年的努力取得显著成效,逐步形成了可推广的乙肝社区综合防治模式。Objective To analyze carrier rate and infection incidence of hepatitis B virus(HBV)and HBV infectionrelated mortality rate among residents of Luohu district,Shenzhen city in 2010 and 2020 for evaluating the effect of comprehensive prevention and control of HBV infection in the region.Methods With stratified multistage cluster random sampling,HBV carrier was surveyed in 2010 and 2020 among residents in Luohu district(a designated demonstration region for viral hepatitis B[HB]prevention and control from 2006).Annual data for years of 2010-2020 on HBV infection incidence,HBV infection-related mortality,and demographics were collected simultaneously for Luohu district and Longgang district(a region in the same city but without implementation of comprehensive intervention on HB)for comparative study.Descriptive epidemiology was adopted in analyses on situations and changing trend of HBV carrier,infection and HBV infection-related mortality.Results Compared to those in 2010(the early implementation stage of comprehensive intervention on HBV infection),the standardized serum positive rate of HBV surface antigen(HBsAg)declined significantly(8.74%vs.6.91%,P<0.01)and the incidence rate of HBV infection decreased by 96.88%(2.88/100000 vs.0.09/100000),but the standardized mortality rate of HB-related diseases fluctuated not significantly(5.36/100000 vs.5.67/100000,P=0.561)among residents of Luohu district in 2020.For the years of 2010-2020,the annual incidence rate of HBV infection in Luohu district were all significantly lower than those in Longgang district(all P<0.05).In comparison with that of Longgang district,the Luohu district’s standardized mortality of HB-related diseases was higher during 2010-2015,basically the same in 2016 and 2017,but significantly lower for years of 2018-2020(P<0.05 for all).Conclusion Ten years after the implementation of the comprehensive prevention and treatment on viral hepatitis B in Luohu district,remarkable results have been achieved and the model for comprehensive intervention on vira

关 键 词：乙型病毒性肝炎 示范 效果评估 现况调查 综合防治 

分 类 号：R183.9[医药卫生—流行病学]