Ultrasound-guided paravertebral nerve block anesthesia on the stress response and hemodynamics among lung cancer patients  

作　　者：Shu-Qing Zhen Ming Jin Yong-Xue Chen Jian-Hua Li Hua Wang Hui-Xia Chen 

机构地区：[1]Department of Anesthesiology,Handan Central Hospital,Handan 056001,Hebei Province,China [2]Department of Anesthesiology,Affiliated Hospital of Hebei University of Engineering,Handan 056002,Hebei Province,China

出　　处：《World Journal of Clinical Cases》2022年第7期2174-2183,共10页世界临床病例杂志

摘　　要：BACKGROUND Thoracic surgery for radical resection of lung tumor requires deep anesthesia which can lead to an adverse inflammatory response,loss of hemodynamic stability,and decreased immune function.Herein,we evaluated the feasibility and benefits of ultrasound-guided paravertebral nerve block anesthesia,in combination with general anesthesia,for thoracic surgery for lung cancer.The block was performed by diffusion of anesthetic drugs along the paravertebral space to achieve unilateral multi-segment intercostal nerve and dorsal branch nerve block.AIM To evaluate the application of ultrasound-guided paravertebral nerve block anesthesia for lung cancer surgery to inform practice.METHODS The analysis was based on 140 patients who underwent thoracic surgery for lung cancer at our hospital between January 2018 and May 2020.Patients were randomly allocated to the peripheral+general anesthesia(observation)group(n=74)or to the general anesthesia(control)group(n=66).Patients in the observation group received ultrasound-guided paravertebral nerve block anesthesia combined with general anesthesia,with those in the control group receiving an epidural block combined with general anesthesia.Measured outcomes included the operative and anesthesia times,as well as the mean arterial pressure(MAP),heart rate(HR),and blood oxygen saturation(SpO;)measured before surgery,15 min after anesthesia(T1),after intubation,5 min after skin incision,and before extubation(T4).RESULTS The dose of intra-operative use of remifentanil and propofol and the postoperative use of sufentanil was lower in the observation group(1.48±0.43 mg,760.50±92.28 mg,and 72.50±16.62 mg,respectively)than control group(P<0.05).At the four time points of measurement(T1 through T4),MAP and HR values were higher in the observation than control group(MAP,90.20±9.15 mmHg,85.50±7.22 mmHg,88.59±8.15 mmHg,and 90.02±10.02 mmHg,respectively;and HR,72.39±8.22 beats/min,69.03±9.03 beats/min,70.12±8.11 beats/min,and 71.24±9.01 beats/min,respectively;P<0.05).There was

关 键 词：Ultrasound-guided paravertebral nerve block anesthesia ANESTHESIA Lung cancer Stress response HEMODYNAMICS 

分 类 号：R614[医药卫生—麻醉学] R734.2[医药卫生—外科学]