Global longitudinal strain is superior to ejection fraction for detecting myocardial dysfunction in end-stage renal disease with hyperparathyroidism  

作　　者：Maria Fernanda Carrasco-Ruiz Antonio Ruiz-Rivera Marvin A Soriano-Ursúa Carlos Martinez-Hernandez Leticia Manuel-Apolinar Carmen Castillo-Hernandez Gustavo Guevara-Balcazar Eunice D Farfán-García Ana Mejia-Ruiz Ivan Rubio-Gayosso Teresa Perez-Capistran 

机构地区：[1]Department of Physiology,Escuela Superior de Medicina,Instituto Politécnico Nacional,Ciudad de México 11340,Mexico [2]Department of Cardiology,Instituto Mexicano del Seguro Social,Ciudad de México 06720,Mexico [3]Endocrine Research Unit,Instituto Mexicano del Seguro Social,Ciudad de México 06720,Mexico [4]Department of Cardiovascular Pharmacology,Instituto Politécnico Nacional,Ciudad de México 11340,Mexico [5]Department of Biochemistry,Escuela Superior de Medicina,Instituto Politécnico Nacional,Ciudad de México 11340,Mexico [6]Education Research,Comisión Nacional Para la Mejora Continua de la Educación,Ciudad de México 03900,Mexico [7]Postgraduate Studies and Research Section,Escuela Superior de Medicina,Instituto Politécnico Nacional,Ciudad de México 11340,Mexico [8]Department of Physiology,Instituto Politécnico Nacional,Mexico City 11340,Ciudad de México,Mexico

出　　处：《World Journal of Cardiology》2022年第4期239-249,共11页世界心脏病学杂志（英文版）（电子版）

基　　金：Supported by the Secretaría de Investigación y Posgrado of the Instituto Politécnico Nacional;the Comisión de Operación y Fomento de Actividades Académicas of the Instituto Politécnico Nacional;the Consejo Nacional de Ciencia y Tecnología

摘　　要：BACKGROUND The estimation of left ventricular ejection fraction(LVEF)by 2D echocardiography(2D-ECHO)is the most used tool to assess LV systolic function(LVSF).Global longitudinal strain(GLS)has recently been suggested as a superior method for several evaluations.This study explored the association and prevalence of LV systolic dysfunction(LVSD)by using these methods in patients with end-stage renal disease(ESRD)and severe hyperparathyroidism(SHPTH);both associated with cardiovascular events(CEs).AIM To evaluate the myocardial function in patients with ESRD and SHPTH by using the GLS and LVEF measured through conventional 2D-ECHO.METHODS In 62 patients with ESRD and SHPTH,asymptomatic,and without a history of CEs,LVSF was evaluated by 2D-ECHO,obtaining the EF,by the Simpson biplane method,and GLS by speckle tracking.RESULTS The total patients with ESRD had a preserved LVEF(>50%)but abnormal GLS(<13.55%).Additionally,multivariate analysis showed an independent association of GLS and serum parathyroid hormone(PTH),LV mass index,and hemoglobin.Also,PTH was independently associated with lateral e'wave and tricuspid regurgitation velocity.CONCLUSION In patients with SHPTH linked to ESRD,the use of GLS by 2D-ECHO is a more sensitive tool than LVEF for detecting LVSD.

关 键 词：Left ventricular hypertrophy Systolic dysfunction Global longitudinal strain End-stage renal disease PARATHORMONE 

分 类 号：R692.5[医药卫生—泌尿科学] R582.1[医药卫生—外科学] R542.2[医药卫生—临床医学]