芪附强心汤治疗心阳虚血瘀型冠心病慢性心力衰竭临床研究  

Clinical Study of Qifu Qiangxin Decoction in the Treatment of Coronary Heart Disease Complicated with Chronic Heart Failure with Syndrome of Deficiency of Heart Yang and Blood Stasis

作　　者：郭宁 张胜高 GUO Ning;ZHANG Shenggao(Department of Cardiology,Suzhou Hospital of Integrated Traditional Chinese and Western Medicine,Suzhou 215101,China)

机构地区：[1]苏州市中西医结合医院心血管内科,江苏苏州215101

出　　处：《中西医结合研究》2022年第2期77-80,88,共5页Research of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨芪附强心汤治疗心阳虚血瘀型冠心病慢性心力衰竭的临床疗效及对患者氨基末端脑钠肽前体(N-terminal pro-brain natriuretic peptid,NT-pro BNP)、血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)、醛固酮(aldosterone,ALD)水平的影响。方法选取本院心血管内科2019年7月—2021年8月收治的心阳虚血瘀型冠心病慢性心力衰竭患者88例,随机分为2组,每组44例。对照组患者予以西医基础治疗,观察组患者在对照组治疗基础上联合芪附强心汤治疗。治疗4周后,比较2组患者临床疗效、治疗前后左心室射血分数(left ventricular ejection fraction,LVEF)、左室舒张末期内径(left ventricular end diastolic diameter,LVEDD)、左室收缩末期内径(left ventricular end systolic diameter,LVESD)、6分钟步行试验(6 minutes walk test,6MWT)距离、NT-pro BNP、AngⅡ、ALD水平。结果治疗后,观察组患者临床治疗总有效率显著高于对照组(P<0.05);观察组患者LVEDD、LVESD显著小于对照组(P<0.05);观察组患者6MWT距离显著长于对照组(P<0.05);观察组患者NT-pro BNP、Ang II、ALD水平显著低于对照组(P<0.05)。结论芪附强心汤治疗心阳虚血瘀型冠心病慢性心力衰竭患者可显著降低NT-pro BNP、Ang II、ALD水平,缩小左心室内径,提高临床疗效。Objective To investigate the clinical efficacy of Qifu Qiangxin decoction in the treatment of coronary heart disease complicated with chronic heart failure with syndrome of deficiency of heart yang and blood stasis and its effect on the levels of N-terminal pro-brain natriuretic peptid(NT-pro BNP),angiotensinⅡ(AngⅡ)、aldosterone(ALD).Methods From July 2019 to August 2021,eighty-eight coronary heart disease complicated with chronic heart failure patients with syndrome of deficiency of heart yang and blood stasis were selected and randomly divided into two groups,with 44 cases in each group.The patients in the control group were treated with basic western medicine,while the patients in the observation group were treated with Qifu Qiangxin decoction on the basis of the treatment in the control group.After 4 weeks of treatment,the clinical efficacy and the levels of left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),6 minutes walking test(6MWT)distance,NT-pro BNP,AngⅡand ALD were compared between the two groups.Results After treatment,the total effective rate of clinical treatment in the observation group was significantly higher than that in the control group(P<0.05).The LVEDD and LVESD in the observation group were significantly lower than those in the control group(P<0.05).The 6MWT distance in the observation group was significantly longer than that in the control group(P<0.05).The levels of NT-pro BNP,Ang II and ALD in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Qifu Qiangxin decoction in the treatment of coronary heart disease complicated with chronic heart failure patients with syndrome of deficiency of heart yang and blood stasis could significantly reduce the levels of NT-pro BNP,Ang II,and ALD,reduce the inner diameter of the left ventricle,and improve the clinical efficacy.

关 键 词：芪附强心汤 冠心病 慢性心力衰竭 心阳虚血瘀证 

分 类 号：R541.4[医药卫生—心血管疾病] R541.6[医药卫生—内科学]