化瘀通便汤不同时辰给药治疗老年慢传输型便秘临床研究  

Clinical Study on the Huayu Tongbian Decoction Administration at Different Times on the Treatment of Slow Transit Constipation in the Elderly

作　　者：王永[1] 陈萌[2] WANG Yong;CHEN Meng(Center of Pelvic Floor,The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110000,China;Outpatient Department,The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110000,China)

机构地区：[1]辽宁中医药大学附属第三医院盆底中心,沈阳110000 [2]辽宁中医药大学附属第三医院门诊部,沈阳110000

出　　处：《中西医结合研究》2022年第2期89-92,99,共5页Research of Integrated Traditional Chinese and Western Medicine

基　　金：国家自然科学基金青年科学基金项目(No.81804094)。

摘　　要：目的探讨化瘀通便汤不同时辰给药治疗老年慢传输型便秘(slow transit constipation,STC)患者的临床疗效。方法选择2017年1月—2019年12月本院收治的180例老年STC患者作为研究对象,根据随机数字表,随机分为卯时组、酉时组、常规组,每组60例。3组患者均采取化瘀通便汤治疗,卯时组于卯时(早晨5~7时)给药、酉时组于酉时(晚17~19时)给药、常规组常规时间(上午8~9时)给药。比较3组患者治疗前后Bristol粪便性状评分、血液流变学指标、结肠传输试验及临床疗效。结果治疗后,3组患者Bristol粪便性状评分、72 h内结肠残留标志物及全血高切黏度、全血低切黏度及血浆黏度水平均明显低于治疗前,且卯时组明显低于酉时组、常规组(P<0.05)。卯时组患者临床治疗总有效率明显高于酉时组、常规组(P<0.05)。结论化瘀通便汤治疗老年STC患者可有效改善临床症状,在卯时给药可进一步提高临床疗效;其治疗机制可能与增加肠道血流量、增强肠动力传输、促进肠蠕动有关。Objective To investigate the clinical efficacy of Huayu Tongbian decoction administered at different times to treat elderly patients with slow transit constipation(STC).Methods One hundred and eighty elderly STC patients admitted to our hospital from January 2017 to December 2019 were selected as the study subjects,and were randomly divided into Maoshi group,Youshi group and conventional group according to the random number table,60 cases in each group.All patients in the three groups were treated with Huayu Tongbian decoction,the Maoshi group was administered at 5-7 am,the Youshi group was administered at 17-19 pm,and the conventional group was administered at 8-9 am.The Bristol fecal trait scores,blood rheological indicators,colological transmission tests and clinical efficacy of the three groups before and after treatment were compared.Results After treatment,the Bristol fecal trait scores,residual colon markers within 72 h,whole blood high cut viscosity,whole blood low cut viscosity and plasma viscosity levels were significantly lower than those before treatment,and the Maoshi group were significantly lower than those in the Youshi group and the conventional group(P<0.05).The total clinical effectiveness of patients in the Maoshi group was significantly higher than that of the Youshi group and the conventional groups(P<0.05).Conclusion Huayu Tongbian decoction on the treatment of elderly STC patients could effectively improve the clinical symptoms,administered at Maoshi could further improve the clinical efficacy,and its therapeutic mechanism might be related to increasing intestinal blood flow,enhancing intestinal power transmission,and promoting intestinal peristalsis.

关 键 词：慢传输型便秘 化瘀通便汤 不同时辰给药 

分 类 号：R256.35[医药卫生—中医内科学]