青蒿素类药物的广谱性及其潜在作用机制的探讨  

A discussion on the broad-spectrum and potential mechanism of artemisinin and its derivatives

作　　者：刘闯 司雯雯 张尹 刘蓉 刘毅 欧阳瑞镯[1] 孙军[2] LIU Chuang;SI Wen-wen;ZHANG Yin;LIU Rong;LIU Yi;OUYANG Rui-zhuo;SUN Jun(School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;Institute for Infectious Diseases and Vaccine Development,School of Medicine,Tongji University,Shanghai 200092,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093 [2]同济大学医学院,传染病与疫苗研究所,上海200092

出　　处：《中国寄生虫学与寄生虫病杂志》2022年第1期114-120,共7页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：上海市教育委员会科研创新计划项目(201901070007E00017)。

摘　　要：青蒿素类药物不仅在治疗疟疾和血吸虫病方面具有独特的疗效,而且在其他疾病的治疗和防治中也具有潜力。越来越多的研究表明,青蒿素及其衍生物具有广泛的功能,这种广谱性正越来越引起人们的重视。本文综述了青蒿素类药物在寄生原虫、寄生蠕虫、病毒、细菌、真菌、昆虫、植物以及癌症疾病中应用的研究成果,并基于其作用的广谱性特征,结合青蒿素通过铁或血红素实现抗疟原虫、抗血吸虫、抗肿瘤效果的作用方式,探讨青蒿素广泛功能背后的潜在作用机制。Artemisinin and its derivatives have unique efficacies in treating of malaria and schistosomiasis,and have potential in the treatment and prevention of other diseases.Increasing evidences have shown that artemisinin and its derivatives have sophisticated functions,and their broad-spectrum characteristics are attracting attention.This article summarizes the existing research on the application of artemisinin class drugs in parasitic protozoa,and parasitic worms,viruses,bacteria,fungi,insects,plants,and other diseases such as cancer and discusses the potential mechanisms behind the broad functions of artemisinin and its derivatives,based on the broad spectrum characteristics of artemisinin class drugs,and their antimalarial,anti-schistosomiasis and antitumor activities through iron or heme.

关 键 词：青蒿素 青蒿素衍生物 作用机制 

分 类 号：R531[医药卫生—内科学]