Cryptococcal antigen testing of lung tissue homogenate improves pulmonary cryptococcosis diagnosis:Two case reports  

作　　者：Wei-Yi Wang Yu-Lu Zheng Li-Bin Jiang 

机构地区：[1]Department of Respiratory Medicine,The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310006,Zhejiang Province,China [2]Department of Respiratory Medicine,The Third Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310000,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2022年第12期3893-3898,共6页世界临床病例杂志

摘　　要：BACKGROUND Pulmonary cryptococcosis(PC)is an opportunistic infectious disease of the respiratory system.Lung tissue biopsies,culture of respiratory samples(e.g.,sputum,lung tissue,pleural fluid,and bronchoalveolar lavage fluid),and cryptococcal antigen(CrAg)testing are helpful for a definitive diagnosis.However,these tests are sometimes falsely negative.PC is often misdiagnosed or underdiagnosed owing to the absence of obvert symptoms,poor imaging specificity,and false-negative laboratory tests.CASE SUMMARY We report two female patients who underwent computed tomography-guided percutaneous needle pulmonary biopsy of a lung nodule for a confirmed diagnosis.In both patients,the CrAg test on the lung biopsy tissue homogenate was positive,while the serum CrAg test was negative.Combined with the lung tissue pathology,we made the diagnosis of PC.Antifungal therapy was effective in both patients.CONCLUSION Given the findings of our cases and the literature review,lung tissue homogenate CrAg testing can be helpful in improving the diagnosis of PC.

关 键 词：Lung tissue homogenate Cryptococcal antigen test Pulmonary cryptococcosis Lung biopsy DIAGNOSIS Case report 

分 类 号：R519.4[医药卫生—内科学] R563.1[医药卫生—临床医学]