人巨细胞病毒感染机体细胞免疫学机制的研究进展  

Research Progress in Immunological Mechanism of Human Cytomegalovirus Infection

作　　者：韦爱萍 宋雅琴 彭薇 谢政军 WEI Aiping;SONG Yaqin;PENG Wei;XIE Zhengjun(Department of Hematology,the Fifth Affiliated(Zhuhai)Hospital of Zunyi Medical University,Zhuhai 519100,China;Zhuhai Campus of Zunyi Medical University,Zhuhai 519000,China)

机构地区：[1]遵义医科大学第五附属(珠海)医院血液内科,广东珠海519100 [2]遵义医科大学珠海校区,广东珠海519000

出　　处：《医学综述》2022年第7期1308-1315,共8页Medical Recapitulate

基　　金：贵州省卫生健康委科技学技术基金项目(gzwjkj2019-1-106);广东省医学科研基金(B2019217)。

摘　　要：人巨细胞病毒(HCMV)感染人体后终身潜伏体内,与人体免疫系统相互作用,其中体液免疫、细胞免疫均参与这一过程。HCMV感染后能在体内持续存在很大程度上与机体细胞免疫长期争斗有关,在感染早期,机体的自然杀伤细胞首先进行免疫应答,之后T细胞参与适应性免疫过程,以上针对HCMV的细胞免疫均能在不同时期控制HCMV的复制和增殖,但HCMV也会削弱机体抗病毒免疫及其他免疫功能,以逃避免疫系统对其控制和限制,从而在体内终身潜伏。进一步了解HCMV感染机体的细胞免疫学机制,可为临床上HCMV特异性T细胞过继细胞免疫治疗HCMV感染性疾病提供依据。After human cytomegalovirus(HCMV)infects human body,it is latent in the body for a lifelong time,and then interacts with the human immune system,in which process both humoral and cellular immunity participate.To a large extent,HCMV can persist in the body after infecting the body,which is related to the long-term struggle of cellular immunity.In the early stage of infection,the body′s natural killer cells first carry out immune response,and then T cells participate in adaptive immunity.The above cellular immunity against HCMV can control its replication and proliferation at different stages.However,HCMV can also lead to the failure of antiviral immunity and other immune functions,in order to escape the control and limitation of the immune system,so it can be latent in the host forever.Further understanding of the cellular immunological mechanism of HCMV infection can provide a reference for the HCMV-specific T cell adoptive immunotherapy for HCMV infectious diseases.

关 键 词：细胞免疫 人巨细胞病毒 自然杀伤细胞 T细胞 免疫逃逸 

分 类 号：R373[医药卫生—病原生物学]