肠道菌群-胆汁酸轴与2型糖尿病关系的研究进展  

Research Progress in Relationship between Intestinal Flora-Bile Acid Axis and Type 2 Diabetes Mellitus

作　　者：周舒婕 杨阳[1] 柯亭羽[1] ZHOU Shujie;YANG Yang;KE Tingyu(Department of Endocrinology,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院内分泌科,昆明650101

出　　处：《医学综述》2022年第6期1180-1185,共6页Medical Recapitulate

基　　金：国家自然科学基金(81760327);云南省卫生健康委员会医学领军人才培养计划(L-2019014)。

摘　　要：2型糖尿病(T2DM)是一种患病率较高的代谢性疾病,以病程漫长、远期并发症复杂多样且难以根治为主要特点,发病机制尚未完全明确。近年来,肠道菌群、胆汁酸与T2DM发生发展的关系是实验室及临床研究的热点。肠道菌群与胆汁酸组成的肠道菌群-胆汁酸轴参与并影响机体葡萄糖代谢及糖稳态调节的过程,与胆汁酸池、胆汁酸受体、胆汁酸信号通路等因素密切相关。因此,深入探索肠道菌群和胆汁酸的相互关系及肠道菌群-胆汁酸轴作用于机体的具体机制有助于发现防治T2DM的新靶点。Type 2 diabetes mellitus(T2DM)is a metabolic disease with a high prevalence,which is characterized by a long course of disease,complicated and diverse long-term complications and difficult cure,and its pathogenesis has not been completely clarified.In recent years,the relationship between intestinal flora,bile acids and the occurrence and development of T2DM has become a hot topic in laboratory and clinical research.The intestinal microbiota-bile acid axis is involved in and affects glucose metabolism and glucose homeostasis regulation,which is closely related to bile acid pool,bile acid receptors and bile acid signaling pathways.Therefore,in-depth exploration of the relationship between intestinal flora and bile acid and the specific mechanism of intestinal flora-bile acid axis on the body is helpful to discover new targets for the prevention and treatment of T2DM.

关 键 词：2型糖尿病 肠道菌群 胆汁酸 胆汁酸受体 

分 类 号：R587.1[医药卫生—内分泌]