胎膜早破孕妇外周血PCT、β-HCG、CRP水平与新生儿并发症发生的相关性研究  

Study on Correlation of Levels of PCT,β-HCG,CRP in Peripheral Blood of Pregnant Women with Premature Rupture of Membranes with Occurrence of Neonatal Complications

作　　者：焦广云[1] 张桂红[1] 王希涛 朱彦贺[1] JIAO Guangyun;ZHANG Guihong;WANG Xitao;ZHU Yanhe(Department of Obstetrics and Gynecology,Daxing District People′s Hospital,Beijing 102600,China)

机构地区：[1]北京市大兴区人民医院妇产科,北京102600

出　　处：《医学综述》2022年第6期1245-1248,F0003,共5页Medical Recapitulate

摘　　要：目的探讨胎膜早破孕妇外周血降钙素原(PCT)、β-人绒毛膜促性腺激素(β-HCG)和C反应蛋白(CRP)水平与新生儿并发症发生的相关性。方法回顾性分析2020年4月至2021年5月北京市大兴区人民医院收治的120例胎膜早破孕妇的临床病历资料,根据是否发生新生儿并发症分为新生儿并发症组(61例)和无新生儿并发症组(59例)。比较两组一般资料,分析胎膜早破孕妇外周血PCT、β-HCG、CRP与新生儿并发症发生的相关性及其单独及联合检测预测新生儿并发症的受试者工作特征曲线下面积(AUC)。结果新生儿并发症组孕妇外周血PCT、β-HCG、CRP水平均高于无新生儿并发症组孕妇[(12.33±2.87)μg/L比(8.69±2.08)μg/L、(4.51±1.13)μg/L比(3.37±0.81)μg/L、(6.11±1.48)mg/L比(4.36±1.02)mg/L](均P<0.01);Logistic回归分析显示,PCT、CRP、β-HCG水平升高是新生儿并发症发生的危险因素(OR=1.514,95%CI 1.203~1.904,P<0.001;OR=3.661,95%CI 2.052~6.535,P<0.001;OR=3.174,95%CI 1.555~6.481,P=0.002)。PCT、β-HCG和CRP与新生儿并发症发生率呈正相关(r=0.632,P=0.003;r=0.659,P=0.002;r=0.664,P=0.001)。PCT、β-HCG和CRP联合检测新生儿并发症发生的受试者工作特征曲线分析结果显示,PCT、β-HCG和CRP三者联合检测预测新生儿并发症的AUC高于各指标单独检测(0.932比0.834、0.829、0.746,P<0.01)。结论胎膜早破孕妇外周血PCT、β-HCG和CRP水平与新生儿并发症的发生有较高相关性,且PCT、β-HCG和CRP联合检测预测新生儿并发症发生的效能优于各指标单独检测。Objective To investigate the correlation of the levels of procalcitonin(PCT),β-human chorionic gonadotropin(β-HCG)and C-reactive protein(CRP)in peripheral blood of pregnant women with premature rupture of membranes with the occurrence of neonatal complications.Methods The clinical medical records of 120 pregnant women with premature rupture of membranes admitted to Daxing District People′s Hospital from Apr.2020 to May 2021 were retrospectively analyzed.According to the occurrence of neonatal complications,they were divided into a neonatal complications group(61 cases)and a non-neonatal complications group(59 cases).The general data of the two groups were compared to analyze the correlation of PCT,β-HCG,CRP in peripheral blood of the pregnant women with premature rupture of membranes with the occurrence of neonatal complications,and the area under the curve(AUC)of neonatal complications predicted by single and combined detections.Results The levels of PCT,β-HCG and CRP in peripheral blood of the pregnant women in the neonatal complications group were higher than those in the non-neonatal complications group[(12.33±2.87)μg/L vs(8.69±2.08)μg/L,(4.51±1.13)μg/L vs(3.37±0.81)μg/L,(6.11±1.48)mg/L vs(4.36±1.02)mg/L](all P<0.01);Logistic regression analysis showed that increased levels of PCT,CRP andβ-HCG were risk factors for neonatal complications(OR=1.514,95%CI 1.203-1.904,P<0.001;OR=3.661,95%CI 2.052-6.535,P<0.001;OR=3.174,95%CI 1.555-6.481,P=0.002).PCT,β-HCG and CRP were positively correlated with the occurrence of neonatal complications(r=0.632,P=0.003;r=0.659,P=0.002;r=0.664,P=0.001).The results of the receiver operating characteristic curve analysis of PCT,β-HCG and CRP combined detection showed that the AUC of PCT,β-HCG and CRP combined detection was higher than that of each indicator alone for the prediction of neonatal complications(0.932 vs 0.834,0.829,0.746,P<0.01).Conclusion The levels of PCT,β-HCG and CRP in peripheral blood of pregnant women with premature rupture of membranes are hig

关 键 词：胎膜早破 降钙素原 C反应蛋白 Β-人绒毛膜促性腺激素 新生儿并发症 相关性 

分 类 号：R714.433[医药卫生—妇产科学]