颅内动脉瘤患者血NLR变化特点及其与Hunt-Hess评分的相关性分析  

The Characteristics of Neutrophil to Lymphocyte Ratio Changes in Patients with Intracranial Aneurysm and its Correlation with Hunt-Hess Score

作　　者：董圆振 夏昆 吴云虎[3] DONG Yuan-zhen;XIA Kun;WU Yun-hu(Graduate School of Anhui University of Chinese Medicine,Hefei 230031,Anhui,China;Anhui Institute of Neurology,Hefei 230031,Anhui,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,Anhui,China)

机构地区：[1]安徽中医药大学研究生院,安徽合肥230031 [2]安徽省神经病研究所,安徽合肥230031 [3]安徽中医药大学第一附属医院,安徽合肥230031

出　　处：《医学信息》2022年第8期101-104,共4页Journal of Medical Information

摘　　要：目的观察并分析颅内动脉瘤患者外周静脉血中性粒细胞与淋巴细胞比值(NLR)水平变化特点及其与Hunt-Hess量表评分的相关性。方法收集2019年1月-2020年12月在安徽中医药大学第一附属医院住院的90例颅内动脉瘤患者资料,其中破裂颅内动脉瘤60例设为A组、未破裂颅内动脉瘤30例设为B组。记录动脉瘤患者入院时首次血常规结果及Hunt-Hess量表评分,比较A、B两组NLR的差异性,以及不同Hunt-Hess分级的动脉瘤患者之间NLR水平差异,并分析NLR与Hunt-Hess评分的相关性。结果A组NLR水平为[7.44(3.10,35.76)],高于B组的[1.59(1.30,1.98)],差异有统计学意义(P<0.05);Hunt-HessⅠ~Ⅴ级患者NLR水平高于Hunt-Hess 0级患者,差异有统计学意义(P<0.05);Hunt-HessⅣ~Ⅴ级患者NLR水平高于Ⅰ~Ⅱ级患者,差异有统计学意义(P<0.05);而Ⅰ级与Ⅱ级、Ⅳ级与Ⅴ级NLR分别比较,差异无统计学意义(P>0.05);NLR与Hunt-Hess分级呈正相关(r=0.843,P<0.05)。结论颅内动脉瘤破裂患者NLR水平升高,NLR与Hunt-Hess分级呈明显的正相关性,将NLR用于评估颅内动脉瘤患者的病情严重程度具有一定的临床应用价值。Objective To observe and analyze the changes of neutrophil to lymphocyte ratio(NLR)level in peripheral venous blood of patients with intracranial aneurysm and its correlation with Hunt-Hess scale score.Methods A total of 90 patients with intracranial aneurysms admitted to the First Affiliated Hospital of Anhui University of Chinese Medicine from January 2019 to December 2020 were collected.Among them,60 patients with ruptured intracranial aneurysms were assigned to group A,and 30 patients with unruptured intracranial aneurysms were assigned to group B.The first blood routine results and Hunt-Hess scale scores of aneurysm patients on admission were recorded to compare the differences in NLR between the two groups,as well as the differences in NLR levels between aneurysm patients with different Hunt-Hess grades,and to analyze the correlation between NLR and Hunt-Hess score.Results The level of NLR in group A was[7.44(3.10,35.76)],which was higher than that[1.59(1.30,1.98)]in group B,and the difference was statistically significant(P<0.05).The level of NLR in Hunt-Hess gradeⅠ-Ⅴpatients was higher than that in Hunt-Hess grade 0 patients,and the difference was statistically significant(P<0.05).The level of NLR in Hunt-HessⅣ-Ⅴpatients was higher than that ofⅠ-Ⅱpatients,and the difference was statistically significant(P<0.05).There was no significant difference in NLR between Hunt-Hess gradeⅠand gradeⅡ,gradeⅣand gradeⅤ(P>0.05).NLR was positively correlated with Hunt-Hess grade(r=0.843,P<0.05).Conclusion The level of NLR in patients with ruptured intracranial aneurysm is increased,and NLR is significantly positively correlated with Hunt-Hess classification.Therefore,it has certain clinical application value to use NLR to evaluate the severity of the condition in patients with ruptured intracranial aneurysm.

关 键 词：颅内动脉瘤 NLR Hunt-Hess评分 相关性分析 

分 类 号：R543[医药卫生—心血管疾病]