酪酸杆菌联合蒙脱石散治疗小儿支气管肺炎继发性腹泻的效果探讨  

Discussion on the Effect of Butyric Acid Bacteria Combined with Montmorillonite Powder in the Treatment of Diarrhea Secondary to Bronchopneumonia in Children

作　　者：胡静 周奇慧 李康 HU Jing;ZHOU Qihui;LI Kang(Department of Pediatrics,Changyuan People's Hospital,Xinxiang 453400,China)

机构地区：[1]河南省长垣市人民医院儿科,河南新乡453400

出　　处：《临床医学工程》2022年第4期473-474,共2页Clinical Medicine & Engineering

摘　　要：目的探讨酪酸杆菌联合蒙脱石散治疗小儿支气管肺炎继发性腹泻的临床效果。方法选取2018年1月至2020年1月我院收治的支气管肺炎继发性腹泻患儿92例,根据用药方案的不同分为观察组(n=48)和对照组(n=44)。在常规治疗基础上,观察组采用酪酸杆菌联合蒙脱石散治疗,对照组仅采用蒙脱石散治疗。比较两组的治疗效果,肠黏膜屏障状态(DAO、D-LAC)及不良反应。结果观察组的治疗总有效率为97.92%,高于对照组的81.82%(P<0.05)。治疗后,两组的血清DAO、D-LAC水平均低于治疗前,观察组的血清DAO、D-LAC水平均低于对照组(P<0.05)。两组治疗期间均未见明显不良反应发生。结论酪酸杆菌联合蒙脱石散治疗小儿支气管肺炎继发性腹泻的效果显著,可有效改善患儿肠黏膜屏障状态,且安全性较高。Objective To explore the clinical effect of butyric acid bacteria combined with montmorillonite powder in the treatment of diarrhea secondary to bronchopneumonia in children.Methods 92 children with diarrhea secondary to bronchopneumonia admitted to our hospital from January 2018 to January 2020 were selected and divided into the observation group(n=48)and the control group(n=44)according to different medication regimens.On the basis of conventional treatment,the observation group was treated with butyric acid bacteria combined with montmorillonite powder,and the control group was only treated with montmorillonite powder.The therapeutic effect,intestinal mucosal barrier status(DAO,D-LAC)and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 97.92%,higher than 81.82%in the control group(P<0.05).After treatment,the levels of serum DAO and D-LAC in both groups were lower than those before treatment,and the levels of serum DAO and D-LAC in the observation group were lower than those in the control group(P<0.05).No obvious adverse reaction occurred in the two groups during treatment.Conclusions Butyric acid bacteria combined with montmorillonite powder in the treatment of diarrhea secondary to bronchopneumonia in children has significant effect and high safety,and can effectively improve the intestinal mucosal barrier status of children.

关 键 词：酪酸杆菌 蒙脱石散 小儿支气管肺炎继发性腹泻 

分 类 号：R725.6[医药卫生—儿科]