Molecular insights into the transgenerational inheritance of stress memory  

作　　者：Qian Zhang Ye Tian 

机构地区：[1]State Key Laboratory of Molecular Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China [2]University of Chinese Academy of Sciences,Beijing 100093,China [3]Center for Excellence in Animal Evolution and Genetics,Chinese Academy of Sciences,Kunming 650223,China

出　　处：《Journal of Genetics and Genomics》2022年第2期89-95,共7页遗传学报（英文版）

基　　金：supported by the National Key R&D Program of China(2017YFA0506400);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000);the National Natural Science Foundation of China(31930023,31771333);supported by the China National Postdoctoral Program for Innovative Talents(BX2021356)。

摘　　要：There is accumulating evidence to show that environmental stressors can regulate a variety of phenotypes in descendants through germline-mediated epigenetic inheritance. Studies of model organisms exposed to environmental cues(e.g., diet, heat stress, toxins) indicate that altered DNA methylations, histone modifications, or non-coding RNAs in the germ cells are responsible for the transgenerational effects. In addition,it has also become evident that maternal provision could provide a mechanism for the transgenerational inheritance of stress adaptations that result from ancestral environmental cues. However, how the signal of environmentally-induced stress response transmits from the soma to the germline, which may influence offspring fitness, remains largely elusive. Small RNAs could serve as signaling molecules that transmit between tissues and even across generations. Furthermore, a recent study revealed that neuronal mitochondrial perturbations induce a transgenerational induction of the mitochondrial unfolded protein response mediated by a Wnt-dependent increase in mitochondrial DNA levels. Here, we review recent work on the molecular mechanism by which parental experience can affect future generations and the importance of soma-to-germline signaling for transgenerational inheritance.

关 键 词：Transgenerational inheritance Environmental stress Epigenetic regulation Noncoding RNAs Mitochondrial DNA content Mitochondrial unfolded protein response (UPRmt) Soma-to-germline signaling 

分 类 号：Q343[生物学—遗传学]