特色制剂制香片治疗骨关节炎的疗效及对血清IL-6、MMP-9水平的影响  

Curative effect of special preparation Zhixiang tablets on osteoarthritis and their influences on serum IL-6 and MMP-9 levels

作　　者：李儒杰 温慧敏[1] 杨沙[1] 陈星宇[2] 冯光富[1] LI Rujie;WEN Huimin;YANG Sha;CHEN Xingyu;FENG Guangfu(Department of Pharmacy,Sichuan Orthopaedic Hospital,Chengdu 610041,China;Department of Lower Limbs,Sichuan Orthopaedic Hospital,Chengdu 610041,China)

机构地区：[1]四川省骨科医院药学部 [2]四川省骨科医院下肢科,四川成都610041

出　　处：《西部医学》2022年第4期571-574,579,共5页Medical Journal of West China

摘　　要：目的探究采用特色制剂制香片治疗骨关节炎的疗效及其对于血清白介素(IL)-6、基质金属蛋白酶-9(MMP-9)水平的影响。方法纳入2018年2月~2020年2月我院收治的135例骨关节炎患者为观察对象,依据随机数字表法按照近似1:1分组原则分为对照组(n=65)与观察组(n=70)。对照组采用西药塞来昔布治疗,观察组则在对照组用药基础上加用制香片治疗。比较两组患者治疗疗效,治疗前后血清IL-6、MMP-9、环氧合酶(COX-2)水平,关节功能指标,骨代谢指标及不良反应发生率。结果观察组患者治疗总有效率明显高于对照组(P<0.05);两组患者治疗后血清指标、关节功能评分指标均显著改善(P<0.05),治疗后观察组患者血清IL-6、MMP-9以及COX-2指标显著低于对照组(P<0.05),治疗后观察组患者WOMAC评分、Lequsene指数显著低于对照组,Lysholm评分显著高于对照组(P<0.05);两组患者治疗前后血磷以及血钙指标差异比较无统计学意义(P>0.05),治疗后β-胶原降解产物(β-CTX)、酒石酸盐酸性磷酸酶异构体(TRACP-5b)、骨特异性碱性磷酸酶(BALP)、骨钙素(BGP)等较治疗前显著改善(P<0.05),治疗后观察组患者β-CTX、(TRACP)-5b低于对照组,BALP、BGP高于对照组(P<0.05);两组治疗后不良反应发生率比较差异比较无统计学意义(P>0.05)。结论骨关节炎患者采用特色制剂制香片治疗可有效下调血清IL-6及MMP-9水平,纠正机体骨代谢紊乱,治疗效果显著,临床应用安全性高。Objective To explore the curative effect of special preparation Zhixiang tablets on osteoarthritis and their influences on levels of serum interleukin(IL)-6 and matrix metalloproteinase-9(MMP-9).Methods A total of 135 osteoarthritis patients who were admitted to the hospital from February 2018 to February 2020 were enrolled as the research objects.According to random number table method,they were divided into control group(n=65)and study group(n=70).The control group was treated with western medicine celecoxib,while study group was treated with Zhixiang tablets on basis of control group.The curative effect,levels of serum IL-6,MMP-9 and cyclooxygenase-2(COX-2)before and after treatment,joint function indexes,bone metabolism indexes,and incidence of adverse reactions were compared between the two groups.Results The total response rate of treatment in study group was significantly higher than that in control group(97.14%vs 86.15%)(P<0.05).After treatment,serum indexes and joint function indexes in both groups were significantly improved(P<0.05).After treatment,serum IL-6,MMP-9 and COX-2 in study group were significantly lower than those in control group(P<0.05).After treatment,the WOMAC score and Lequsene index of the study group were significantly lower than those of the control group,and the Lysholm score was significantly higher than that of the control group(P<0.05).Serum phosphorus and blood calcium showed no statistically significant differences between the two groups before and after treatment(P>0.05).After treatment,β-collagen degradation product(β-CTX),tartrate resistant acid phosphatase isoform 5b(TRACP)-5b,bone alkaline phosphatase(BALP),and bone gla protein(BGP)were significantly improved(P<0.05).After treatment,β-CTX and(TRACP)-5b in the study group were lower than those in the control group,while BALP and BGP were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between study group and control group after treatment(P>0.05).Conc

关 键 词：特色制剂制香片 骨关节炎 疗效 IL-6 MMP-9 

分 类 号：R684.3[医药卫生—骨科学]