内源性刺激响应策略在肿瘤精准诊疗中的应用  

Progress on Application of Endogenous Stimuli Responsive Strategies in Tumor Precision Theranostics

作　　者：赵旭[1,2,3] 王孟超 张抗抗 严秀平 ZHAO Xu;WANG Meng-chao;ZHANG Kang-kang;YAN Xiu-ping(State Key Laboratory of Food Science and Technology,Jiangnan University,Wuxi 214122,China;International Joint Laboratory on Food Safety,Jiangnan University,Wuxi 214122,China;Institute of Analytical Food Safety,School of Food Science and Technology,Jiangnan University,Wuxi 214122,China)

机构地区：[1]江南大学食品科学与技术国家重点实验室,江苏无锡214122 [2]江南大学国际食品安全联合实验室,江苏无锡214122 [3]江南大学食品学院,分析食品安全学研究所,江苏无锡214122

出　　处：《分析测试学报》2022年第4期587-592,共6页Journal of Instrumental Analysis

基　　金：国家自然科学基金项目(21804056);江苏省自然科学基金项目(BK20180581);博士后科学基金项目(2018M630511)。

摘　　要：肿瘤微环境具有低pH值、乏氧、高谷胱甘肽含量、过表达酶以及氧化应激增加等系列异常特征。这些内源性差异在肿瘤增殖、侵袭、迁移以及新生血管生成等环节发挥重要作用,同时也为肿瘤精准诊疗提供了机遇。开发内源性刺激响应型诊疗剂已成为肿瘤精准诊疗领域的研究热点。该文综述了近年来发展的各类内源性刺激响应型诊疗体系的设计原理及其在肿瘤精准诊疗中的应用,并展望了该领域面临的问题及发展趋势,旨在为新型智能诊疗体系的构建提供理论依据和参考。The microenvironment of tumor has a series of abnormal features,including low pH values,hypoxia,excess glutathione,increased oxidative stress and overexpressed enzymes.These endogenous factors play an important role in tumor proliferation,invasion,migration and neoangiogenesis,but they also provide opportunities for tumor precision diagnosis and treatment.The development of endogenous stimuli responsive platforms has become a research hotspot.Therefore,the design principles and the recent progress of various kinds of endogenous stimuli responsive diagnosis and treatment agents developed in recent years are summarized in this paper.The challenges and perspectives of the stimuli responsive platforms are discussed with a view to providing a theoretical basis for the construction of intelligent theranostics system.

关 键 词：内源性 刺激响应 精准诊疗 肿瘤 研究进展 

分 类 号：O657[理学—分析化学] G353.11[理学—化学]