Schnitzler综合征1例  

A Case of Schnitzler Syndrome

作　　者：伍迪[1] 李杰 严妍[1] 王金容 赵丽娟[1] 杨雪松[1] 叶建州[1] 黄虹[1] WU Di;LI Jie;YAN Yan;WANG Jinrong;ZHAO Lijuan;YANG Xuesong;YE Jianzhou;HUANG Hong(Department of Dermatology,Yunnan Hospital of Traditional Chinese Medicine,Kunming 650021,China;Department of Chronic Disease Management,the Third People's Hospital in Kunming,Kun-ming 650000,China)

机构地区：[1]云南省中医医院皮肤科,云南昆明650021 [2]昆明市第三人民医院慢病管理科,云南昆明650000

出　　处：《中国皮肤性病学杂志》2022年第1期78-83,共6页The Chinese Journal of Dermatovenereology

基　　金：云南中医药大学第一附属医院中医药防治皮肤病省创新团队(2019HC001)。

摘　　要：患者女,45岁,四肢、躯干反复荨麻疹样皮损伴发热、关节痛1年。体检:双腋下和腹股沟可触及肿大淋巴结。皮损组织病理示:真皮浅层血管周围散在淋巴细胞和中性粒细胞浸润。实验室检查:白细胞、C反应蛋白和红细胞沉降率持续升高;血液免疫固定电泳示:IgM轻链κ型单克隆免疫球蛋白。骨扫描示:右侧肱骨远端、双侧股骨中下段、左侧胫骨异常代谢活跃。诊断:Schnitzler综合征。经环孢素联合秋水仙碱治疗后,症状部分缓解。A 45-year-old female patient presented with recurrent urticarial rash in extremities and trunk, accompanied by fever and joint pain for one year.Physical examination showed double axilla and groin could be touched with enlarged lymph nodes.Histopathological examination showed scattered lymphocytes and neutrophils were observed around superficial dermal vessels.Laboratory tests showed WBC,CRP and ESR were consistently elevated. Blood immunofixation electrophoresis showed IgM light chain κ monoclonal immunoglobulin.Bone scans showed abnormal metabolic activity in the right distal humerus, bilateral middle and lower femurs, and left tibia.A diagnosis of Schnitzler syndrome was made.After treatment with cyclosporine and colchicine, the symptoms was partially alleviated.

关 键 词：Schnitzler综合征 临床特点 文献回顾 

分 类 号：R597[医药卫生—内科学]