紫外线介导的细胞间相互作用影响黑素合成研究进展  

Advances in Effect of Ultraviolet-Mediated Intercellular Interaction on Melanin Synthesize

作　　者：蒋鑫 常锦绣 胡敏[1] 杨雅琪 赵薇[1] 吴盼 孙思昊 顾华[1] JIANG Xin;CHANG Jinxiu;HU Min;YANG Yaqi;ZHAO Wei;WU Pan;SUN Sihao;GU Hua(Department of Dermatology,the First Affiliated Hospital of Kunming Medical University,Dermatology Hospital of Yunnan Province,Kunming 650000,China)

机构地区：[1]昆明医科大学第一附属医院皮肤科云南省皮肤病医院,云南昆明650000不详

出　　处：《中国皮肤性病学杂志》2022年第1期113-117,共5页The Chinese Journal of Dermatovenereology

基　　金：云南省卫生和计划生育委员会医学学科带头人培养计划(D-2017038);云南省科技厅-昆明医科大学应用基础研究联合专项面上项目(2019FE001-047)。

摘　　要：皮肤是人体最大的器官,由表皮、真皮及皮下组织构成。表皮黑素细胞是合成黑素的场所,其黑素合成过程受到外环境(紫外线等)及内环境(表真皮细胞分泌的细胞因子、化学递质、分泌型蛋白质等)的共同影响。本文将对紫外线介导的角质形成细胞、成纤维细胞、肥大细胞、内皮细胞对黑色素合成过程的影响进行综述。Skin is the largest organ of human body which consists of epidermis, dermis and subcutaneous tissue.Epidermal melanocytes are the factory that could synthesize melanin.The process of melanogenesis is influenced by the external environment(ultraviolet) and internal environment(cytokines, chemical transmitters and secretory proteins secreted by skin cells).In order to provide new ideas for melanin synthesize, the effect of UV-mediated cell-cell interaction on the melanogenesis is summarized in this paper.

关 键 词：紫外线 黑素合成 黑素细胞 角质形成细胞 成纤维细胞 肥大细胞 内皮细胞 

分 类 号：R758.42[医药卫生—皮肤病学与性病学] R363[医药卫生—临床医学]