中国慢性阻塞性肺疾病患者骨质疏松患病率的meta分析  

Prevalence of osteoporosis in patients with chronic obstructive pulmonary patients in China:A meta-analysis

作　　者：黄平 杨浩 刘汉芸[2] 李玉红[2] HUANG Ping;YANG Hao;LIU Han-yun;LI Yu-hong(Graduate School,Qinghai University,Xining Qinghai,810000,China;Department of Respiratory Diseases,Qinghai University Affiliated Hospital,Xining Qinghai,810000,China)

机构地区：[1]青海大学研究生院,青海西宁810000 [2]青海大学附属医院呼吸科,青海西宁810000

出　　处：《职业与健康》2022年第5期690-694,共5页Occupation and Health

基　　金：青海省科技计划项目(2018-ZJ-T04);青海大学中青年科研基金项目(2019-QYY-12);青海省“昆仑英才·高端创新创业人才”项目。

摘　　要：目的系统评价我国慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者骨质疏松(osteoporsis,OP)患病率情况。方法计算机检索PubMed、Embase、Web of science、中国知网、万方等数据库,收集有关中国COPD患者OP患病率的相关文献,检索时限均为建库至2021年3月。由2名研究人员独立完成文献筛选、数据提取以及对纳入文献的质量评价,采用Stata 14.0软件对纳入的数据进行meta分析。结果中国COPD患者OP患病率为33.3%(95%CI:24.9%~42.3%)。亚组分析显示,男性患病率低于女性,年龄≥60岁患病率更高,南方地区人群患病率低于北方,吸烟人群患病率高于未吸烟人群,应用激素人群患病率高于未使用激素者,肺功能受损越严重患病率越高。结论我国COPD患者OP患病率较高,且其患病率受性别、年龄、地区、肺功能受损严重程度等因素影响。针对COPD人群,应采取措施进行干预,以减少COPD患者OP的发生。Objective To evaluate the prevalence of osteoporosis(OP)in patients with chronic obstructive pulmonary patients(COPD)systematically in China.Methods Searching PubMed,Embase,Web of science,CNKI,Wanfang by computer to collect relevant literature on the prevalence of OP in patients with COPD in China.The search time limit was from inception to March2021.Two researchers independently completed the screening of the literature,the extraction of data and the quality evaluation of the included literature.Stata 14.0 software were used to perform meta-analysis.Results The prevalence of OP in patients with COPD in China was 33.3%(95%CI:24.9%-42.3%).The results of subgroup analysis showed that the prevalenceof men was lower than women,the prevalence was higher in the age≥60 years old,the prevalence in the south was lower than than in north,and the prevalence of smokers was higher than that of non-smokers,the prevalence of people who used hormones was higher than without hormones.The more severe the lung function,the higher the prevalence.Conclusions The prevalence of OP in patients with COPD in China is relatively high,and its prevalence is affected by factors such as gender,age,region,and severity of lung function.For patients with COPD,clinical measures should be taken to intervene to reduce the occurrence of OP in patients with COPD.

关 键 词：慢性阻塞性肺疾病 骨质疏松 患病率 META分析 

分 类 号：R181.3[医药卫生—流行病学]