中性粒细胞在组织修复中作用及机制的研究进展  

Research progress in role and mechanism of neutrophils in tissue repair

作　　者：王健[1] 陆芸 杨小锋[1,4] Wang Jian;Lu Yun;Yang Xiaofeng(Emergency and Trauma Center,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 311121,China;Cancer Institute,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Department of Obstetrics and Gynecology,Shanghai First Maternity and Infant Hospital,School of Medicine,Tongji University,Shanghai 200092,China;Department of Neurosurgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属第一医院急诊创伤中心,杭州311121 [2]上海中医药大学附属龙华医院肿瘤研究所,上海200032 [3]同济大学医学院,同济大学附属第一妇婴保健院妇产科,上海200092 [4]浙江大学医学院附属第一医院神经外科,杭州310003

出　　处：《中华创伤杂志》2022年第3期268-273,共6页Chinese Journal of Trauma

基　　金：国家自然科学基金(81900591)。

摘　　要：皮肤、肌肉、骨及神经等组织损伤可对机体造成不同程度的损害,严重时导致器官功能障碍,甚至危及生命。为恢复受损组织的结构和功能,各种免疫细胞和组织细胞先后参与了组织修复过程。中性粒细胞作为终末分化的白细胞,在组织损伤发生后可通过吞噬作用及分泌抗菌物清除病原体和组织碎片,为后续的组织修复创造条件,但是过度的中性粒细胞募集和炎症反应可能加重组织损伤。近年来有研究表明,中性粒细胞存在异质性和可塑性,并且在启动组织修复、促进血管生成、调节细胞增殖等方面均发挥着重要作用。笔者就中性粒细胞在组织修复中的募集、表型与功能、修复作用及结局进行综述,为后期相关研究提供参考。Damage to skin,muscle,bone and nerve tissues can result in various degrees of damage to the body,leading to organ dysfunction even life-threatening.To restore the structure and function of the damaged tissues,various immune cells and histocytes have successively participated in the tissue repair process.As the terminally differentiated white blood cells,neutrophils can remove necrotic tissue,debris and pathogens via phagocytosis and release of antimicrobial peptides after tissue injury to provide conditions for subsequent tissue repair process.However,enhanced neutrophils recruitment as well as excessive inflammatory response may also aggravate tissue damage.In recent years,more and more evidences indicate that neutrophils display plasticity and heterogeneity and that play critical roles in the initiation of tissue repair,promotion of angiogenesis,regulation of cell proliferation and so on.Herein,the authors review the recruitment,phenotype and function,role and outcome of neutrophils during tissue repair so as to provide references for future studies.

关 键 词：中性粒细胞 炎症 细胞因子类 组织修复 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]