补中益气汤加减联合西药治疗支气管哮喘临床研究  

Clinical Study on Modified Center-Supplementing and Qi-Boosting Decoction Combined with Western Medicine in the Treatment of Bronchial Asthma

作　　者：覃芳[1] 焦莉 QIN Fang;JIAO Li(Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China,450008)

机构地区：[1]河南中医药大学第三附属医院,河南郑州450008

出　　处：《河南中医》2022年第5期712-715,共4页Henan Traditional Chinese Medicine

基　　金：河南省中医药科学研究专项课题项目(2018ZY2104)。

摘　　要：目的:观察补中益气汤加减联合西药治疗支气管哮喘的临床疗效。方法:将107例支气管哮喘患者按照随机数字表法分为研究组54例和对照组53例。对照组给予常规西药治疗,研究组在对照组治疗的基础上给予补中益气汤加减治疗。比较两组患者的临床疗效、不良反应发生率及治疗前后中医证候积分、夜间憋醒次数、嗜酸性粒细胞(eosinophils,EOS)、白细胞介素-5(interleukin-5,IL-5)、肺功能[第1秒用力呼气容积(forced expiratory volume in one second,FEV1)、呼气流量峰值(peak expiratory flow,PEF)、用力肺活量(forced vital capacity,FVC)]变化情况。结果:对照组有效率为81.13%,研究组有效率为96.30%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后胸膈满闷、咯痰、咳嗽等中医证候积分低于本组治疗前,且治疗后研究组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后夜间憋醒次数、EOS、IL-5低于本组治疗前,且治疗后研究组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后FEV1、FVC、PEF高于本组治疗前,且治疗后研究组高于对照组(P<0.05)。研究组不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论:补中益气汤加减联合西药治疗支气管哮喘,可改善患者临床症状及炎性因子水平,减少夜间憋醒次数,提高肺功能。Objective:To observe the clinical curative effect of Modified Center-Supplementing and Qi-Boosting Decoction combined with Western Medicine on bronchial asthma.Methods:A total of 107 patients with bronchial asthma were randomly divided into the study group with 54 cases and the control group with 53 cases.The control group was treated with conventional Western medicine,and the study group was treated with Modified Center-Supplementing and Qi-Boosting Decoction on the basis of the treatment of the control group.The clinical efficacy,incidence of adverse reactions,the changes of TCM syndrome score,times of waking up at night,eosinophils(EOS),interleukin-5(IL-5) and lung function [including forced expiratory volume in one second(FEV1),peak expiratory flow(PEF),forced vital capacity(FVC)] before and after treatment.Results:The effective rate of the control group was 81.13%,and that of the study group was 96.30%.There was significant difference between the two groups(P<0.05).After treatment,the TCM syndrome scores of chest and diaphragm fullness,expectoration and cough in the two groups were lower than those of the same group before treatment,and the above indexes of the study group were lower than those of the control group after treatment,and all the differences were statistically significant(P<0.05).The times of waking up at night,EOS and IL-5 in the two groups after treatment were lower than those before treatment,and the above indexes of the study group were lower than those of the control group after treatment,and all the differences were statistically significant(P<0.05).FEV1,FVC and PEF of the two groups after treatment were higher than those of the same group before treatment,and the above indexes of the study group were higher than those of the control group after treatment(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Modified Center-Supplementing and Qi-Boosting Decoction combined wi

关 键 词：支气管哮喘 补中益气汤加减 中西医结合疗法 

分 类 号：R256.12[医药卫生—中医内科学]