长期吸烟者大脑半球水平动态功能连接密度改变的磁共振成像研究  

Altered inter-and intrahemispheric functional connectivity dynamics in long-term smokers

作　　者：张孟哲 黄荟玉 高昕宇 杨镇圭 文萌萌 汪卫建 程敬亮[1] 张勇[1] Zhang Mengzhe;Huang Huiyu;Gao Xinyu;Yang Zhengui;Wen Mengmeng;Wang Weijian;Cheng Jingliang;Zhang Yong(Department of MRI,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院磁共振科,郑州450052

出　　处：《中华精神科杂志》2022年第2期98-105,共8页Chinese Journal of Psychiatry

基　　金：河南省重点研发与推广专项(科技攻关)项目(212102310712)。

摘　　要：目的采用具有时变分析功能的动态功能连接密度(dynamic functional connectivity density,dFCD)探究长期吸烟者全脑和半球水平脑功能网络的动态性改变。方法纳入符合DSM-Ⅳ中关于物质依赖诊断标准的37例长期吸烟者(长期吸烟组),以及年龄、受教育年限与之相匹配的健康对照者47名(对照组),采集静息状态功能磁共振成像数据及一般人口学资料。将全脑功能连接分解为半球间和半球内功能连接,使用滑动窗口方法计算每个体素的全脑、半球间和半球内dFCD值。利用半球内和半球间的标准差进一步量化功能连接动态的时间变异性。采用双样本t检验比较长期吸烟组与对照组间dFCD值的差异。结果与对照组相比,长期吸烟组在左侧岛叶、左侧壳核的全脑dFCD值升高(t=3.99、4.49)。在半球间水平比较中,长期吸烟组在左侧岛叶、左侧壳核的dFCD值较对照组升高(t=3.81、4.33)。在半球内水平比较中,长期吸烟组较对照组左侧岛叶、左侧壳核的dFCD值升高(t=4.20、4.33),与全脑和半球间dFCD值的改变有相似的模式(均高斯随机场校正,体素水平P<0.005,团块水平P<0.05)。结论长期吸烟者左侧岛叶和左侧壳核的功能连接模式的时变性反映了它们与大脑其他区域的异常通信,揭示了半球水平功能连接异常在成瘾机制中可能的潜在作用。Objective To explore the neuro mechanism of tobacco addiction,this study applied the dynamic functional connectivity density(dFCD)to analyze the dynamic changes of brain functional networks at both whole-brain and hemisphere levels in long-term male smokers.Methods Thirty-seven smokers met the criteria for substance addiction according to the Diagnostic and Statistical Manual of Mental Disorders-Four Edition(DSM-Ⅳ)and 47 healthy controls matched with age and education were recruited.Resting-state functional magnetic resonance imaging(rs-fMRI)data and clinical data were collected in both smokers and healthy controls.The whole-brain functional connectivity was decomposed into ipsilateral and contralateral functional connectivity.Sliding-window analysis was utilized to capture the intra-and interhemispheric dFCD patterns.The temporal variability of the functional connectivity dynamics was further quantified using the standard deviation(SD)of intra-and inter-hemispheric dFCD over time.The two-sample t-test was used to compare dFCD variance between the two groups.Results Compared with healthy controls,smokers showed increased global dFCD variance in the left insula and left putamen(t=3.99,4.49).Increased dFCD variability was observed in the left insula and left putamen among smokers compared with healthy controls when comparing dFCD variability at both intra-(t=4.20,4.33)and interhemispheric(t=3.81,4.33)level(Gaussian Random Field GRF corrected,voxel P<0.005,cluster P<0.05).Conclusion Among long-term smokers,a time-varying characteristic of functional connectivity patterns was observed in the left insula and left putamen,which reflects the abnormal communication between these brain areas and other brain areas.The alteration of intra-and interhemispheric dynamic functional connectivity may be the underlying neuro mechanism of tobacco addiction.

关 键 词：磁共振成像 吸烟 功能连接密度 大脑半球 

分 类 号：R445.2[医药卫生—影像医学与核医学] R163[医药卫生—诊断学]