药物代谢酶的表型转化与精神药物治疗  

Phenoconversion of drug-metabolizing enzymes and pharmacotherapy of mental disorders

作　　者：牟凡 赵雪[2] 李华芳[3] 禹顺英[1] Mou Fan;Zhao Xue;Li Huafang;Yu Shunying(Genetic Laboratory of Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China;Department of Psychiatry,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China;Institution of Drug Clinical Trial,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心遗传室,上海200030 [2]上海交通大学医学院附属精神卫生中心精神科,上海200030 [3]上海交通大学医学院附属精神卫生中心药物临床试验机构,上海200030

出　　处：《中华精神科杂志》2022年第2期145-149,共5页Chinese Journal of Psychiatry

基　　金：上海交通大学医工交叉重点项目(YG2019ZDA30);上海市精神心理疾病临床医学研究中心(19MC1911100);上海市精神卫生中心(SHMC)临床研究中心2021年度项目(CRC2021ZD02)。

摘　　要：药物代谢酶的表型转化是指药物代谢酶的表型在特定的非遗传因素影响下发生暂时性变化的现象。药物与疾病是引起表型转化的主要因素,若忽略其影响,易导致临床治疗效果欠佳、增加药物不良反应等风险。由于相当一部分精神药物,尤其是抗抑郁药对代谢酶有不同程度的抑制作用,易引起表型转化,所以在精神疾病患者的个体化药物治疗中需要密切关注表型转化。本文对药物代谢酶表型转化在精神药物治疗中的研究进展进行综述。Phenoconversion of drug-metabolizing enzymes refers to the phenomenon that the phenotype of drug-metabolizing enzymes changes temporarily under specific non-genetic factors.Medicines and diseases are the main factors that cause phenoconversion.If its potential effects are ignored,it is easy to lead to poor clinical treatment effects,adverse drug reactions,and other risks.Most psychotropic medications,especially antidepressants,have different inhibitory effects on metabolic enzymes,which can easily cause phenotypic transformation.Therefore,phenoconversion is an important aspect of individual drug therapy for patients with mental disorders.This article reviewed the progress in the study on phenoconversion of drug metabolism enzymes in psychotropic medicines.

关 键 词：精神治疗药物 药物代谢酶 表型转化 

分 类 号：R969[医药卫生—药理学]