Iron-catalyzed cyanoalkylation of difluoroenol silyl ethers with cyclobutanone oxime esters  

作　　者：Xiaolei Zhu Yangen Huang Xiuhua Xu Fengling Qing 

机构地区：[1]College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China [2]Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Science,Chinese Academy of Science,Shanghai 200032,China

出　　处：《Chinese Chemical Letters》2022年第2期817-820,共4页中国化学快报（英文版）

基　　金：National Natural Science Foundation of China (Nos.21421002,21991211);the Strategic Priority Research Program of the Chinese Academy of Sciences (No.XDB20000000)。

摘　　要：An iron-catalyzed coupling reaction of difluoroenol silyl ethers and cyclobutanone oxime esters is described. This protocol provides a convenient access to various previously unknown and potentially useful gem-difluoromethylenated ketonitriles inmoderate to good yields. The transformations of resulting products to other fluorinecontaining products is also documented.

关 键 词：Cyanoalkylation Difluoroenol silyl ether Cyclobutanone oxime ester Iron catalysis Radical reaction 

分 类 号：O621.251[理学—有机化学]